Cancer Immunology & Prevention

Disguising patient's own "immune soldiers" by mutated PD-1

Isolate patient's own CD8+ T cells, or use HLA matched healthy donor's CD8+ T cells. Shut down the PD-1 expression, and engineer those T cells express mutated PD-1. The mutation site is intracellular which will cause impaired PD-1 signaling pathway.

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