Facilitating interoperability across various data repositories as well as novel and harmonized data analytic tools that can be used across different systems: Many hematologic diseases, including those that impact the pediatric population are categorized as rare diseases. The rare, yet deleterious nature of these diseases (e.g., chronic myelomonocytic leukemia) make it challenging to build a critical mass of data, that can be leveraged to inform research questions, therapy development and/or practice patterns related to these diseases. The American Society of Hematology (ASH) has recognized such limitations and has invested in the creation of the ASH Research Collaborative (ASH RC) Data Hub to facilitate the sharing of data on hematologic malignancies such as multiple myeloma in support of scientific inquiry and discovery. Through this initiative, the National Cancer Institute could help facilitate interoperability across various data repositories as well as novel and harmonized data analytic tools that can be used across different systems. This will facilitate crosstalk between various data repositories like the ASH Data Hub and ensure that all repositories are learning and benefiting from each other.