Tumor Evolution & Progression

Field effect and promoter hypermethylation

"Field-effect" and its importance in cancer has been proposed in the 50's. Hypermethylation can silence some tumor suppressor genes while cause some genes to overexpress.

What is the research problem

Early cancer detection at a molecular level not when lesions are observed

How will your solution make a difference

Detecting cancer way early when molecular changes occur.

What is your proposed solution

An objective study on the biology (not epidemiology study) of Inflammation and anti-inflammatory pathway genes influenced by field effect at promoter level will advance our understanding and strategies to slow or even thwart cancer progression.

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Idea No. 28