Tumor Evolution & Progression

Identify the stem cell minority in malignant brain tumors

High grade gliomas are the deadliest brain tumors known. Despite a combination of surgery, radiation, and chemotherapy, most patients die within 2 years. We need to identify the stem cell minority and target them with advanced therapies.

What is the research problem

High grade gliomas are the deadliest brain tumors. There is currently no established method for identifying and specifically targeting progenitor cells believed to be responsible for tumor recurrence and progression.

How will your solution make a difference

We should be able to cure this deadly cancer in the next ten years. It will require a moonshot initiative, but it will save millions of lives and many years of productivity lost otherwise.

What is your proposed solution

Recent research in rats has shown that there are stem-like cells with positive CD15 staining. These cells may be the primary target, but further research is needed. Different from ordinary x-rays, ion radiation therapy can overcome the resistance and reduce the aggressive behavior of these cells. We will need a moonshot approach to bring ion therapy back to the U.S. and integrate it into new therapeutic approaches.

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