Siloed data repositories are often not interoperable, therefore, it is important to think beyond a traditional data repository and consider other types of data infrastructure solutions that can accommodate diverse data. APIs and principles set forth by communities such as the Data Biosphere and GA4GH are a few examples of how researchers are utilizing technologies to link data repositories. NCI should further define requirements for interoperability under a Findable, Accessible, Interoperable, and Reusable (FAIR) framework for childhood cancer while also creating policies that encourage data lifecycle management including provenance. "FAIR"-ness must be at the forefront of data management. To that end, open-source data management tools such as iRODS can help bridge the worlds of policy and technology to enable data sharing in a compliant and FAIR manner.