Cancer Immunology & Prevention

RadiationTherapy &anti-PD1 antibodyfor unresectable mesothelioma

A phase 1 trial of a short course of high dose radiation therapy to an escalating volume of unresectable mesothelioma followed immediately by an anti-PD1 antibody.

How will your solution make a difference

A phase 1 trial would demonstrate that such a unique strategy to combat mesothelioma is safe and feasible. A followup phase 2 trial would demonstrate efficacy.

What is your proposed solution

Radiation therapy (RT) has profound effects on the tumor microenvironment causing elimination of regulatory T cells, presentation of neo antigens, amongst other. RT can potentiate the effect of immune checkpoint inhibitors such as anti-PD1 antibodies. A phase 1 trial investigating escalating the gross tumor volume irradiated with a short course of high dose radiation immediately followed by an anti-pd1 antibody.

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Idea No. 860