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Study Spontaneous Cancers in Companion Animals as Models

Dogs naturally get cancer - >1million per year diagnosed and treated.Old, young,various genetics,share our environment and suffer complications and side-effects of treatment. Dogs represent an authentic model of human cancer and have similar biology.

What is the research problem

Lab rodents do not represent humans - varied genetics, age, and co-morbidities, often failing to predict treatment success and costing time and money via misdirection. Rare/pediatric cancers lack population numbers for trials.

How will your solution make a difference

Case study: recent work in a new brain cancer drug suggests savings of 5 years and millions of dollars since biodistribution, safety, starting dose, and patient selection were all de-risked in dogs with brain tumors in the course of a single year.

What is your proposed solution

Enroll more companion animals in clinical trials with cancers that parallel human disease, invest in the sequencing of spontaneous animal cancers to comprehend the similarities and differences - already many identical pathways have been identified. Some rare/pediatric cancers occur plentifully in the dog population and offer resource for study options.

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Idea No. 839

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