Cancer Immunology & Prevention

Random DNA methylation from low in-situ formaldehyde production

Food contents calculations suggest human methanol BAC below the 1 ppm measurement noise level. This results in a low level of metabolically produced formaldehyde in blood vessel linings, mammary tissue and connective tissue. Develop an animal model

What is the research problem :

Can low-level metabolic production of formaldehyde in the cytosol of non-liver tissues eventually induce cancers by means of random DNA methylation? All animals utilize catalase, which confines the formaldehyde to the interior of peroxisomes.

How will your solution make a difference :

The 20-30% increase in cancer rates cited by NCI during 1975-1985 coincides with a significant increase in society's inadvertent consumption of methanol. So this study may lead to reduced incidence of cancers in high-vascular organs & mammary tissue

What is your proposed solution :

Genetically engineered mice will have to have three simultaneous genetic modifications - human catalase, ADH1 in the same tissues as humans, and with similar ADH1/ADH3 ratios. The main limitation of this approach is the short lifetime of mice compared to the apparent years of exposure time in humans. Time scaling with methanol blood alcohol concentration elevated to 1-10 ppm or more will be used.


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Idea No. 494