Pediatric Cancer

Cancer Research Ideas - Pediatric Cancer (Archived)

Children are not just small adults; their cancers are different in many ways from those in older individuals. Improving childhood cancer outcomes requires both a better mechanistic understanding of cancer in general as well as an understanding of cancer in children specifically. Important issues to address include the molecular drivers of childhood cancer, which are often different from those of adult cancers; the causes of childhood cancer; and the development of therapies that are less toxic to children’s developing bodies.

The submission period for Pediatric Cancer ideas ended on July 1. However, we encourage you to sign up for regular e-mail updates about the National Cancer Moonshot Initiative at the Cancer Moonshot Milestones web page.

Research Area: Pediatric Cancer

Catch Childhood Cancer Early with Simple Blood Test & CDA Tech

Protect kids from risky imaging & increase early detection success by analyzing simple blood tests using multi-level/parameter algorithm & Cancer Differentiation Analysis devices; 30K cases confirm CDA identifies 16 cancers-often before tumors form.

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What is the research problem :

Pediatric check-ups don’t include comprehensive cancer screening like invasive testing/imaging due to radiation/other hazards. Kids are screened only when symptoms persist & aren’t attributed to other diseases-finally identifying cancer Stage2+.

How will your solution make a difference :

90% of children with cancer can survive the disease & avoid long/traumatic/expensive treatments, if it’s caught Stage 1. CDA provides easy/accurate cancer screening through simple blood tests, without the child experiencing negative side effects.

What is your proposed solution :

30K cases confirm CDA devices detect 16 different cancers by analyzing simple, non-invasive blood tests using CDA’s multi -level/parameter diagnostic tech-achieving 75-90% sensitivity/specificity-measurably more accurate than most conventional screening.CDA’s inexpensive; produces no patient side effects; generates fewer false positives; allows for safe & accurate cancer screening during regular pediatric check-ups through normal blood draws.

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Research Area: Pediatric Cancer

Children Are More Vulnerable to Cell Phone Brain Cancer Risk

According to WHO/IARC children absorb two times higher cell phone radiation in the brain and 10 times higher radiation in the skull bone marrow as compared to adults.

Research shows higher brain cancer risk in those who started using phones young.

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What is the research problem :

Children are given Wi-Fi devices as toys. Clinicians and parents are largely unaware that cell phones and wireless devices emit radiation classified as Class 2B carcinogen (2011). Recent research adds more weight to evidence showing carcinogenicity.

How will your solution make a difference :

Reducing children's exposures at home and in school- where they spend the most time will decrease children's cumulative lifetime exposure to microwave RF-EMF.

Data collection/analysis on exposure/diagnosis is key to characterize pediatric impacts.

What is your proposed solution :

Current evidence suggests that children are more vulnerable to the potential carcinogenic effects of cell phones and other microwave-emitting technologies (RF).

Prevention efforts to reduce exposure are urgently needed. Pediatric cancer patients are even more vulnerable and they and their families need to learn how to reduce exposures to promote recovery.

Systematic data needs to be collected on patient RF exposures at diagnosis.

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Research Area: Pediatric Cancer

HAMLET-protein kills cancer cells and multiresistant bacteria

HAMLET binds to and kills many different types of cancer cells in vitro. It has been successfully tested on animals and has also had good effect in humans with cancer. The effect is to my knowledge limited in plasma. Hamlet has no known sideeffects..

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What is the research problem :

Use HAMLET in large scale global studies on cancer-patients, lung, colon, esofagus, skin, bladder, mouth, nose, spinal canal, metastasis... Modify it so it has good effect also in blood, I have heard that it binds to albumin which reduces its effect.

How will your solution make a difference :

Cancerpatients can hopefully be cured without getting sideffects and cancer can be prevented by HAMLET. Multiresistant bacteria on skin or in wounds could hopefully be killed by antibiotics. I think that HAMLET will eventually generate a Nobel prize.

What is your proposed solution :

I really think that HAMLET could be a global revolutionary breakthrough when it comes to treating many different types of cancers without the patient getting sideeffects. In studies they have seen that HAMLET makes multiresistant bacteria sensitive to ordinary antibiotics again. I have many ideas about clinical trials, patient treatment, applications, diagnosis and medication and would really like to become involved in this project, Contact me!

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Research Area: Pediatric Cancer

Coping Support for diagnosis and treatment

Providing comprehensive tools that help families cope emotionally with a diagnosis, treatment and beyond.

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What is the research problem :

There is a lack of uniform care to help address the emotional aspects of cancer that exist beyond the medical treatment. One study found that 49% of adolescents develop mild to severe Post Traumatic Stress Symptoms following cancer treatments.

How will your solution make a difference :

Providing families with coping resources will help children and their families to cope with their illness while building resiliency to thrive in the future.

What is your proposed solution :

Resources need to be developed and their effectiveness measured to ensure that all needs are met for the family. These resources should also be housed in a central place so families can easily access them, whenever they need them.

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Research Area: Pediatric Cancer

Childhood Cancer Survivorship

NIH funding for childhood cancer research equals only 4% of the budget for cancer research), and funding for survivorship research is only a fraction. There are significant health risks to surviving cancer, especially for children.

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What is the research problem :

Childhood cancer survivors (400,000 in the US) are increasing in number; however, morbidity is also increasing. What is needed now is acceleration of discoveries that will prevent devastating, costly late effects of cancer and treatment.

How will your solution make a difference :

Optimal cure involves physical/psychological health, economic stability and independence. Through data/resource-sharing and multi-site studies, dissemination of evidence-based interventions reduces/prevents morbidity in childhood cancer survivors.

What is your proposed solution :

We advocate creative partnerships focused on catalyzing scientific breakthroughs in tertiary prevention to avoid/ameliorate late/lasting complications and maintain high cure rates. Robust multi-institutional studies to improve health and quality of life are lacking. We envision a collaborative network of innovative clinician-scientists, parent/survivor advocates, and other disciplines (e.g., genetics/genomics) focused on survivorship research.

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Research Area: Pediatric Cancer

Early Integration of Palliative Care for Children with Cancer

Early integration of palliative care for children with cancer can mitigate suffering. There is a pressing need to accelerate research that defines how best to extend the benefits of early integration of palliative care in the cancer trajectory.

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What is the research problem :

The research problems include mitigating symptom distress and addressing barriers to implementing pediatric palliative care in a curative setting; including access to services, decreasing the need to choose between palliative or curative treatment.

How will your solution make a difference :

It is anticipated that accelerating discoveries in palliative care will increase access to these services and improve utilization of resources so that expert palliative care will be available to all who are suffering from the ravages of cancer.

What is your proposed solution :

The proposed solution is funding innovative research that addresses Improved access to palliative care services early in the cancer trajectory through collaborative partnerships; national operationalization of the Concurrent Care Act to ensure adequate mechanisms for palliative care and expansion of education to build primary palliative cancer care competencies for bedside clinicians in areas not well served by palliative care specialists.

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Research Area: Pediatric Cancer

Palliative Care in children with cancer who live in middle east

Medical treatments and lack of attention to the complications have led to frequent hospitalizations, more family involvement, increased treatment costs, etc., and ultimately reduced quality of life for children with cancer and their families.

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What is the research problem :

Cancer children cancer and their families need palliative care in middle east countries to reduce cost of care, readmission and increased QOL. Therefore, developing PC system as an unmet need, should be considered as a health priority in this region.

What is your proposed solution :

Integrate palliative care in health care system.

Increasing policy makers, health providers and public awareness.

Using models of palliative care for children in middle east countries.

Financial support with the participation of charities / NGO.

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Research Area: Pediatric Cancer

Radiogel. A Smart Bullet for Cancer!

This is in dedication to my father who was the ultimate Cancer Fighter! He was President of the National Association of Cancer Patients and all he wanted was to cure cancer! He felt he had a solution with medical isotopes but especially Radiogel.

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What is the research problem :

The company that has the rights to Radiogel to treat cancer has to go through lengthy bureaucratic processes. It could save lives instead of the fear of hesitation. Radiogel has been shown to be safe and effective. The patients and kids are suffering

How will your solution make a difference :

My niece did this video, dedicated to my father! This is completely unauthorized by the company. My dad would have insisted I post it and wouldn't care if I/he got in trouble. Fear of a cure!

What is your proposed solution :

My father helped develop Radiogel, and all he cared was getting it to the patients. He was so adamant about getting patients a treatment but the "business people" told him to calm down and not to talk to patients because it was not FDA approved. He would always tell people he had a "cure for cancer" and everyone told him, you can't use the word "cure"! He didn't care about the $ or commercialization! It didn't happen in his lifetime. Radiogel

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Research Area: Pediatric Cancer

Pediatric cancer mainly develops in still developing cells.

The biggest requirement for new cells in a child will be in still developing cells, or cells with a quick turnover. These are cells where cancer could be produced if cell cycle is inhibited. At 6, the requirement to regenerate cells is diminished.

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What is the research problem :

Researchers do not realize that Pediatric Cancers result from a failure to start the G1 phase of the cell cycle.

This is explained in more detail in my attachment. Click on "Comments" to see the attachment.

How will your solution make a difference :

As long as you know what the mutation is that causes the cancer, a pharmaceutical treatment should be able to be produced to treat that specific cancer. Any treatment must be intermittent as you will be altering the cell cycle.

What is your proposed solution :

For each kind of pediatric cancer you will have to determine what mutation is causing that cancer. The treatment solution will have to overcome the mutation and allow the G1 phase of the cell cycle to start. All pediatric cancers such as Leukemia, Brain Tumors, and Neuroblastoma etc. are all undergoing a requirement for newly developing cells. These all require a working G1 phase of the cell cycle. Check CDK Cyclin D1 levels to prove loss of G1.

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Research Area: Pediatric Cancer

Family Support to Facilitate Care at Research Centers

Pediatric cancer affects the whole family, and resources may be lacking to take a child to a research center for best quality of care and access to clinical trials.

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What is the research problem :

Children with cancer may not be able to go to research centers for care and to participate in clinical trials due to their families not having enough sustained financial and other support. This can especially impact children in rural areas.

How will your solution make a difference :

This solution will result in more children participants for clinical trials. It will result in more children with cancer having access to best care. It will help level disparities in care snd improve care for rural residents.

What is your proposed solution :

All funding for pediatric cancer research should include provision for generous financial support for families of clinical trial participants, as needed. Funding should also be provided for other children to come to the research center for care even if not eligible for a clinical trial on an agreed upon ratio. Support can include travel costs, income replacement, and access to support services in home area.

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Research Area: Pediatric Cancer

Children's Cause for Cancer Advocacy, Founder & Chair

A new corporation is needed to minimize cost and risk to biopharma of discovering and developing new anti-cancer agents for children. It will exploit new science and coordinate resources efficiently to bring effective new therapies to children.

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What is the research problem :

Knowledge of childhood cancer biology is yielding smaller patient groups that will require unique novel therapies. Therapeutic development for children is not commercially profitable and is not aligned to address children’s needs for new therapies..

How will your solution make a difference :

A company dedicated to discovery and development of anti-cancer agents for children will maximize selection of effective new therapies, shorten the time for pediatric access and focus research and development on resistant and refractory cancers.

What is your proposed solution :

A new national public/private corporation needs to be formed to assume financial and development risks of bringing safer and more anti-cancer agents to children. A corporate business model can attract private, government and philanthropic investment, manage and translate scientific findings into therapeutic development. Alternative models to solve this problem exist and require national level analysis and evaluation to move forward for children.

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Research Area: Pediatric Cancer

From cause to prevention

The causes of pediatric cancer remain a mystery because its rarity necessitates case-control studies. However, now that variants related to ALL and NB are known, one can conceive of a putting together a prospective study among higher-risk kids

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What is the research problem :

Most research on childhood cancer etiology is retrospective and prone to bias. Prospective studies would be superior but have been difficult because of rarity.

How will your solution make a difference :

A well-conducted cohort study will answer questions about the causes of ALL and neuroblastoma that have lingered for over thirty years due to a reliance on case-control studies.

What is your proposed solution :

The combination of gene variants associated with ALL and neuroblastoma now define a population of children with moderately high risk of these cancers (i.e. ~10X greater than background). This puts incidence at a level where a cohort study is feasible for two of the most common childhood cancers. Working with a state newborn screening program or health plan, kids can be genotyped and those with highest risk invited into a seminal cohort study.

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