Cancer Immunology & Prevention

Participation

Accelerate trials of car T cell immuotherapy for prostate cancer

How will your solution make a difference

It has shown a difference for other cancer patients in the use of this such as melanoma. Terminal prostate cancer patients such as myself at the end of standarized treatments have no choices left.

What is your proposed solution

Provide funding for this as City of Hope was ready to go forward with this, but lacked necessary funding and every where you look as a potential groundbreaking treatment car T cell immuotherapy is mentioned for advanced prostate cancer.

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Cancer Immunology & Prevention

Adaptive memory NK cells targeted though CD16

We believe that NK cells, like T cells, have the capacity, to be antigen specific specific through the low affinity binding of CD16 to natural antibody or high affinity binding of tri-specific killer engagers (TriKEs) that also proliferate NK cells.

How will your solution make a difference

We hypothesis that adaptive NK cells, that have all the machinery of T cells, will offer non-cross resistant therapy to advanced cancer, will be safer than T-CAR and can be made antigen specific, antigen proliferative and be long lived.

What is your proposed solution

We have discover a novel population of CMV-induced adaptive NK cells that have a hypomethylation signature that resembles CD8+ T cells more so than conventional NK cells that are long-lived and have enhanced signaling through CD16. Novel immune engagers that bind CD16 at high affinity with a single chain Fv can be combined with a modified IL-15 linker to impart proliferation and a single chain Fv to make adaptive memory NK cells antigen specific.

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Cancer Immunology & Prevention

Stimulate immunoresponse to tumor in situ

Cancerous tumors have vasculature which allows them to receive nutrients and grow. The body recognizes these tumors as "self" early in the process and allows this support system to grow.

How will your solution make a difference

My idea is inexpensive, easy to evaluate and can be implemented using existing technologies that exist all over the world.

What is your proposed solution

My idea is to use this blood system to distribute blood of a different type in high concentration but low volume at the site of the tumor to stimulate an immune response and destroy the tumor.

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Cancer Immunology & Prevention

RadiationTherapy &anti-PD1 antibodyfor unresectable mesothelioma

A phase 1 trial of a short course of high dose radiation therapy to an escalating volume of unresectable mesothelioma followed immediately by an anti-PD1 antibody.

How will your solution make a difference

A phase 1 trial would demonstrate that such a unique strategy to combat mesothelioma is safe and feasible. A followup phase 2 trial would demonstrate efficacy.

What is your proposed solution

Radiation therapy (RT) has profound effects on the tumor microenvironment causing elimination of regulatory T cells, presentation of neo antigens, amongst other. RT can potentiate the effect of immune checkpoint inhibitors such as anti-PD1 antibodies. A phase 1 trial investigating escalating the gross tumor volume irradiated with a short course of high dose radiation immediately followed by an anti-pd1 antibody.

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Cancer Immunology & Prevention

Investigate Rothschild Family

The wealthiest people in the world have unique access to vaccines and cures, and go to great lengths to deny the rest of the world these treatments in the interest of profit.

How will your solution make a difference

These investigations could expose evidence of plausibly deniable mass genocide. Investigate Memorial Sloan Kettering Hospital research on Laetrile therapy. By making vitamin B17 available, cancer cells can be destroyed before they become problematic.

What is your proposed solution

Investigate the wealthiest people in the world including the Rothschild family to learn their cancer experiences. Investigate how leading cancer researchers and physicians have prevented and treated cancer themselves. Investigate clinical trials and the FDA for falsification. Investigate drug companies, cancer treatment equipment manufacturers, and cancer research centers searching for a cure, to uncover corruption.

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Cancer Immunology & Prevention

Vaccinate population against certain Human Papilloma Virus

Human papilloma virus can cause cancer. It is well known that vaccination against certain types of HPV reduces the risk of getting cancer.

How will your solution make a difference

Fewer males and females will get cancer as well as HPV associated warts/condyloma.

What is your proposed solution

Start by vaccinating females and males under the age of 40. When that is done diskussion should be made about who else should get vaccinated.

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Cancer Immunology & Prevention

BOOST ANTIGEN-PRESENTATION COMBINED WITH CHECK-POINT INHIBITION

Down-regulation of (neo)antigens limits the efficacy of immune-checkpoint inhibitors. Interferon-g is a potent stimulator of MHC expression and antigen-presentation. Administration of systemic IFNg may boost checkpoint-inhibitors.

How will your solution make a difference

If toxicity can be managed for the proposed combination therapy, this treatment could result in expanding the response rate and duration of remission of treatment with immune check-point inhibitors for a variety of cancers.

What is your proposed solution

Interferon-g (IFNg) is the most potent inducer of expression of MHC I and II molecules and of antigen-processing and presentation. IFNg has been used systematically before (and toxicity, while present, can be managed). Thus we should design clinical trials for the combination of immune check-point inhibitors with systemic IFNg. One should also screen for novel small molecules that could enhance MHC and antigen expression

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Cancer Immunology & Prevention

Can some cancers be contageous between humans?

I have heard that dogs can get cancer from being infected with cancercells from their partner while mating. I have heard of families where two individuals die of cancer or of the same type of cancer shortly after eachother. Is this a coincidence?

How will your solution make a difference

If some cancer in humans is contagious that would change routines in Healthcare and within families. Perhapas better advice could prevent other familymembers and Healthcare staff from getting cancer.

What is your proposed solution

Examine if human cancercells can cause cancer in human tissue/cells from another person. Can onk-genes or other types of genes that regulates the cellcycle and division of a cell be transferred by microbes or by close contact between humans? Are there any human cancercells that are contagious? Use Big-data to see what familymemebers die from. Perform gene-sequencing to look for similar causes of cancer within the same family.

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Cancer Immunology & Prevention

Examine correlation between infections and cancers

I have heard that there is a microbiology instrument that from one drop of blood can find traces of over 100 different infections that a person has been exposed to during her lifetime.

How will your solution make a difference

If there is an unknown correlation between microbes and cancer a vaccine should be developed. Vaccination would hopefully generate fewer cancerpatients.

What is your proposed solution

Analyze cancerpatients blood and search for infections they have had during their life, compare the results with healthy people to see if some exposures are more common among different types of cancerspatients.Use big-data.

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Cancer Immunology & Prevention

Prevention Efforts: Reducing Exposure to Cell Phones and Wi-Fi

The National Toxicology Program finding that rats exposed to radio-frequency (RF) radiation developed increased brain and heart cancer adds to the weight of evidence showing that RF (from cell phones/wi-fi) is carcinogenic. http://goo.gl/4E5Ecq

How will your solution make a difference

Acting Now Will Protect Children's Future. Children will have a lifetime of exposure to wireless radiation. Simple steps can dramatically reduce their exposures. Preventative action will protect their health, wellbeing and future. ehtrust.org

What is your proposed solution

The USA can develop prudent cautionary policy to reduce cell phone/Wi-Fi exposures to the public with special attention to children, pregnant women and the medically vulnerable.

The As Low As Reasonably Achievable - ALARA- principle can be applied to cell phones, wireless and other EMF radiation. ALARA is a well known radiation safety principle for minimizing radiation doses and is a regulatory requirement for radiation safety programs.

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Cancer Immunology & Prevention

Prevention is the best cure

We need a shift toward a more positive attitude regarding cancer prevention, rather than a focus on treatment alone.

How will your solution make a difference

There is a tendency to disbelieve when the proposed lifestyle change is inconvenient. But more research and an attitude change towards prevention will save people from unpleasant treatment regimens and help them lead longer, healthier lives.

What is your proposed solution

Fund grants that identify links between environmental causes and cancer, using epidemiology data and biochemistry to recognize trends and discern molecular causes. To motivate people to make changes, the scientific community first needs to focus on rather than scoff at preventative research. Mounting evidence regarding the role of BMI in breast cancer, for example, should be followed up on, and similar inquiries emphasized across cancer types.

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Cancer Immunology & Prevention

Moon trial: 384 400 patients treated with personalized vaccines

It is 384 400 km to the moon. This trial aims to treat one patient with a personalized cancer vaccine for each kilometer to the moon - by the end of the decade.

How will your solution make a difference

Many researchers believe personalized cancer vaccines targeting neoantigens may represent a universal cure for many types of cancer. If they are right, this trial will make a major contribution towards discovering these cures.

What is your proposed solution

A very large trial where (384 400 patients) with multiple arms that will test a wide range of vaccine designs and delivery methods in a range of cancers. A common base would be whole exome sequencing of tumor and normal tissue to identify tumor specific mutations as well as RNA sequencing. Based on this, various delivery mechnisms (peptides, mRNA, DNA, etc) will be tested, as well as various adjuvants, injection methods/sites, dosing, etc.

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Cancer Immunology & Prevention

I Think I have a long term solution to all cancers.

What if we just isolated the gene that each strain of cancer is connected to and weeded it out of the gene pool?

How will your solution make a difference

While the current treatment for cancers are mostly successful my idea would provide a future of NO cancer. No it wouldn't be a short term solution but I believe that it is a good idea to consider.

What is your proposed solution

To isolate the genes that cancers have in common and try to remove it from the gene pool.

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Cancer Immunology & Prevention

Optimizing checkpoint efficacy by combining with targeted agents

Current immune-oncology research is focused on a limited number of checkpoint targets. Identification of new targets that improve the efficacy when combined with approved checkpoint antibodies would represent an important cancer treatment advance.

How will your solution make a difference

Translation of a well understood spectrum of in vivo predictive models to studies in the clinical setting would aid the field in understanding how best to predict and represent clinical activity through nonclinical research in Immuno-oncology.

What is your proposed solution

Choosing a model to study tumor/immune system interactions is complicated by the diversity and characteristics of in vivo models (i.e. syngeneic, GEMM, humanized models ). Clinically-relevant combination strategies can be found by use of a matrix of models in a systematic and unbiased approach. Kinase inhibitors are a proven drug class and are promising candidates as combinatorial agents to be studied in the systematic manner suggested here.

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