It is 384 400 km to the moon. This trial aims to treat one patient with a personalized cancer vaccine for each kilometer to the moon - by the end of the decade.
Cancer Immunology & Prevention
Cancer Research Ideas - Cancer Immunology & Prevention (Archived)
In the past few years, the rapidly advancing field of cancer immunology has produced several new methods of treating cancer, called immunotherapies, that increase the strength of a patient’s immune responses against tumors. Such treatments have led to dramatic successes in some cancers but not others. At the same time, the concept of adjusting the immune response, or immunomodulation, is being extended into cancer prevention, with the goal of developing strategies to spur the immune system to both prevent the development of cancer in the first place and prevent recurrence.
The submission period for Cancer Immunology & Prevention ideas ended on July 1. However, we encourage you to sign up for regular e-mail updates about the National Cancer Moonshot Initiative at the Cancer Moonshot Milestones web page.
What if we just isolated the gene that each strain of cancer is connected to and weeded it out of the gene pool?
Current immune-oncology research is focused on a limited number of checkpoint targets. Identification of new targets that improve the efficacy when combined with approved checkpoint antibodies would represent an important cancer treatment advance.
A lifestyle change of how we view and treat one another combined with a scripture based fast or diet that is in line with scientific findings to achieve healing.
A paradigm in cancer control is to combat cancer by reversing tumor hypoxia. A critical barrier to treatment would be to turn off expression of hypoxia-driven genes and restore tumor sensitivity to radiotherapy, chemotherapy, and immunotherapy
Pharmacological interrogation of the kinome with small molecule tool sets used in phenotypic screens is an approach to discover novel targets and new drugs. Molecules that improve and expand the efficacy of current immunotherapy would result.
There is a great need to find biomarkers predicting response to developing immune therapies. Germ-line microRNA binding site mutations are a recently discovered, powerful new type of biomarker of response to cancer therapy, including immune therapy.
Additional research is needed on psychological interventions for depressed cancer patients and survivors to speed their recovery and enhance quality of life.
Additional support is needed to perform fundamental studies of the relationship between stress and disease-specific inflammation markers -- thus far one only one study looks at patients with blood cancer.
HPV causes >91% of cervical, 91% of anal and 72% of oropharyngeal cancers. HPV infection affects 79 million Americans and is preventable by vaccination. Mandatory school-based vaccination eliminates barriers to this essential cancer prevention.
There is strong evidence that radiation therapy can trigger an anti-tumor immune response even leading to the disappearance of metastasis not radiated. We need to better understand the mechanisms involved.
Develop biomarkers by analysis of body fluids or cells to identify individuals susceptible to cancer so prevention and surveillance can be initiated, and to identify targeted therapies that are most likely to be effective in specific cancer patients.