Cancer Immunology & Prevention

Integrated healing approach based on science and scriptures

A lifestyle change of how we view and treat one another combined with a scripture based fast or diet that is in line with scientific findings to achieve healing.

How will your solution make a difference

Lord willing, it could possibly heal a lot of people.

What is your proposed solution

Follow a strict multi-year unique diet - as outlined in the attached research. The diet considers research at the University of California’s longevity institute, University of Wisconsin’s evolution research, Bioethics research at Princeton University, etc.
Live a purposeful lifestyle rich in loving relationships as outlined by the University of Michigan’s life development institute or Harvard’s 75 year research on healthy living for Happiness.

Voting

0 votes
Ideate

Cancer Immunology & Prevention

Combating Cancer By Reversing Tumor Hypoxia

A paradigm in cancer control is to combat cancer by reversing tumor hypoxia. A critical barrier to treatment would be to turn off expression of hypoxia-driven genes and restore tumor sensitivity to radiotherapy, chemotherapy, and immunotherapy

How will your solution make a difference

New advancements in nanotechnology and nanoparticles will provide the opportunity and platform for new investigator-initiated trials and establish a better understanding of tumor hypoxia, its biology, and exploitation as a new therapeutic tool.

What is your proposed solution

Tumor re-oxygenation can be accomplished by utilizing nanotechnology applications that will increase the effectiveness of chemotherapy and immunotherapy while validating safe therapies to battle tumor hypoxia.

Voting

0 votes
Ideate

Cancer Immunology & Prevention

Harnessing the TME to increase efficacy of checkpoint antibodies

Pharmacological interrogation of the kinome with small molecule tool sets used in phenotypic screens is an approach to discover novel targets and new drugs. Molecules that improve and expand the efficacy of current immunotherapy would result.

How will your solution make a difference

Current efforts in immune-oncology are focused on a limited set of checkpoint targets. Identification of kinases that potentially enhance the efficacy of currently approved checkpoint antibodies would represent a novel approach to cancer treatment.

What is your proposed solution

An annotated collection of small molecules that inhibit kinases and used in phenotypic screens would identify novel targets that limit the efficacy of cancer immunotherapies. Immuno-oncology is well suited to phenotypic screening as primary immune cells are used in disease relevant assays. Kinases are a proven enzyme class, and the availability of enabling technologies (e.g. kinome selectivity screens) allows for rapid target prosecution.

Voting

0 votes
Ideate

Cancer Immunology & Prevention

Germ-line miRNA based biomarkers of altered immunity

There is a great need to find biomarkers predicting response to developing immune therapies. Germ-line microRNA binding site mutations are a recently discovered, powerful new type of biomarker of response to cancer therapy, including immune therapy.

How will your solution make a difference

It is logical that biomarkers of the immune response should be germ-line, and in all cells of the immune system. MicroRNA binding site mutations are powerful new directors of biological responses, including immunity, and are an avenue for answers.

What is your proposed solution

The first discovered germ-line mutation that disrupts microRNA binding sites in important oncogenes was the KRAS-variant, and is an inherited mutation in the KRAS oncogene. We have shown that the KRAS-variant predicts baseline altered immunity and that cancer patients with the KRAS-variant have a unique response to different immune therapies. We propose to test additional similar mutations as biomarkers of immune treatment.

Voting

0 votes
Ideate

Cancer Immunology & Prevention

Cancer and Depression

Additional research is needed on psychological interventions for depressed cancer patients and survivors to speed their recovery and enhance quality of life.

How will your solution make a difference

Recovery from cancer is not only a matter of tumor eradication. Psychological variables predict cancer survivors’ ability to return to work or pre-cancer function. Depression has been related to slower rates of return to work (Spelten, et al, 2003).

What is your proposed solution

Psychological interventions can reduce inflammation and risk for recurrence. Andersen and colleagues (2008, 2009) have demonstrated that reducing psychological difficulties can improve disease processes such as inflammation and survival in breast cancer patients.

Voting

0 votes
Ideate

Cancer Immunology & Prevention

Biobehavioral Research on Stress and Immune Function

Additional support is needed to perform fundamental studies of the relationship between stress and disease-specific inflammation markers -- thus far one only one study looks at patients with blood cancer.

How will your solution make a difference

These basic studies may reveal targets for intervention to reduce stress, inflammation and enhance immune function in a broader range of cancer patients and survivors.

What is your proposed solution

To date, PNI cancer research has focused on solid tumors (Lutgendorf and Andersen, 2016), with reliable demonstrations of the covariation of stress and T-cell and Natural Killer (NK) cell cytotoxicity (Andersen et al, 1998), behavioral factors and psychological responses and cytokine levels (e.g. Costanzo et al, 2005; Breitbart, et al, 2014; Howren, Lamkin & Suls, 2009), or experiments in which distress is reduced and immunity is enhanced.

Voting

0 votes
Ideate

Cancer Immunology & Prevention

Eradicate HPV as cause of cancer in US

HPV causes >91% of cervical, 91% of anal and 72% of oropharyngeal cancers. HPV infection affects 79 million Americans and is preventable by vaccination. Mandatory school-based vaccination eliminates barriers to this essential cancer prevention.

How will your solution make a difference

A school-based vaccination program could eliminate the 57,000 HPV-associated cancers seen each year and 18,000 deaths due to this disease. HPV precancerous conditions and substantial associated morbidity could also be reduced dramatically.

What is your proposed solution

Society of Gynecologic Oncology proposes mandatory school-based vaccination for all children in US. This would help track vaccination rates, ensure completion of all doses and provide catch-up vaccination for those students who are not vaccinated within the age guidelines. The nonavalent HPV vaccine would cover 82-94% high risk HPV subtypes. Advances in HPV vaccination would allow us to immunize the already exposed US population--about 85%.

Voting

0 votes
Ideate

Cancer Immunology & Prevention

Intensify research on radiation-induced tumor immunoresponse

There is strong evidence that radiation therapy can trigger an anti-tumor immune response even leading to the disappearance of metastasis not radiated. We need to better understand the mechanisms involved.

How will your solution make a difference

Metastases kill cancer patients. More than 50% of cancer patients currently received radiation therapy. Therefore, the potential is enormous if we discovered how to best employ radiation treatment to consistently elicit anti-tumor immunoactivation.

What is your proposed solution

Intensify research on mathematical modeling, laboratory, pre-clinical and clinical studies to unlock anti-tumor radiation-induced immunoactivation.

Voting

0 votes
Ideate

Cancer Immunology & Prevention

Biomarkers for personalized cancer prevention and therapy

Develop biomarkers by analysis of body fluids or cells to identify individuals susceptible to cancer so prevention and surveillance can be initiated, and to identify targeted therapies that are most likely to be effective in specific cancer patients.

How will your solution make a difference

These approaches can decrease cancer incidence and mortality by personalizing prevention and therapy. Even partial success would save millions of lives per year.

What is your proposed solution

For prevention, analysis of blood, urine, or DNA by mass spectrometry provides metabolic or DNA damage patterns identifying high risk individuals who can be targeted for intensive surveillance and prevention. For therapy, analysis of body fluids or tumor samples provides metabolomics, genomic, and epigenomic data which together with an understanding of the micro and macro tumor environment, can lead to successful targeted therapy.

Voting

0 votes
Ideate

Cancer Immunology & Prevention

Strive to Thrive

Strengthening the immune system by using what we have available from nature including food, herbal supplements, mistletoe therapy, biomat, mindfulness, positive emotions, exercise, social support, stress reduction and more.

How will your solution make a difference

Best case will be cure, next will be improved QoL, third will be prevention. Healthy lifestyles not only will improve our wellbeing but will cut costs for medical insurance, loss of work, premature loss of life. It also will provide happier people.

What is your proposed solution

Dr Kelly Turner wrote a book Radical Remission that has analyzed over 1000 of these cases around the world which shows 9 factors they all had in common to heal their cancer. Create Integrative Oncology programs incorporating these healing factors as an option for people going through treatment. If it does not help in curing them, it will help in their QoL and possible prevention. None of these are harmful and worthwhile to provide relief.

Voting

0 votes
Ideate

Cancer Immunology & Prevention

Plant-based foods to reduce the risk of cancer

Community Member kudos icon + Community member

To test and eventually market foods enriched in chemopreventive agents.

How will your solution make a difference

Populations will have access to scientifically-determined plant-based enriched foods that will reduce the risk of cancer (and other diseases). These foods may also be used to enhance cancer treatment response.

What is your proposed solution

Basic science research has established the mechanisms by which constituents in foods reduce different cancer risks. Food enriched in these constituents can be grown. These foods can be tested in individuals who are considered to be at high risk for specific cancers and who are likely to benefit from them. Biomarkers associated with cancer mechanisms, including those associated with the immune system and inflammation, can be assessed.

Voting

0 votes
Ideate

Cancer Immunology & Prevention

immune regulation therapy

You can see the attachment for summary.

How will your solution make a difference

The patients live longer and have more energy and can come to normal work. So far we didn't see any side effects by using our new ways.

What is your proposed solution

In our two books wrote down all of the solutions:
New concept and new ways of treatment fo cancer; On innovation of treatment of cancer .

Voting

0 votes
Ideate

Cancer Immunology & Prevention

Cross-disciplinary study of immunology

What can be learned about cancer immunology from the study of tolerance in human pregnancy, or from the study of tumor rejection in other species with naturally occurring cancers?

How will your solution make a difference

Hopefully new approaches would be identified to improve immune-based treatments for human cancers.

What is your proposed solution

To improve immune-based approaches to treating human cancers, I wonder what can be learned indirectly from other settings, such as how tolerance occurs in human pregnancy, or how other species reject naturally occurring malignancies. These are not new concepts but I wonder if cross-disciplinary research could lead to new insights and approaches.

Voting

0 votes
Ideate

Cancer Immunology & Prevention

Test women over 30 yrs old for high or Irregular hormone levels

Develop a reasonably priced test (blood or other) to determine if a women has a high or irregular level of hormones, estrogen, progesterone, whatever.

How will your solution make a difference

Most breast cancer is hormone driven, if a woman knows when she is 30 or 35 that her hormones are high she could change her lifestyle and/or take medication to make it normal preventing breast cancer altogether. Won't solve all but will help.

What is your proposed solution

Develop a test that every women could be given that would determine her hormone levels to see if they are high or irregular.

Voting

0 votes
Ideate

Cancer Immunology & Prevention

National (internatl ?) Registry of vegans and plant-based eaters

Fruits & veggies seem to protect against & ⬇️ progression of cancers of the mouth, throat, larynx, esophagus, stomach, lung, pancreas, prostate. Excluding meat may protect against colon cancer, childhood leukemias.

How will your solution make a difference

Reduced cancer death rates, increased quality of life and survival in cancer patients.
Reduced death rates from CV, diabetes, obesity, IBD, neuro-inflammatory diseases.

Understand better the role of the microbiome in cancer development, progression.

What is your proposed solution

Implement the largest registry of ethical vegans and plant-based eaters. Analyze cancer-related deaths & compare them to cancer deaths in the general population.

Sample the microbiota of participants in a convenience sample

Voting

0 votes
Ideate