Transfusions may alter clinical outcomes in cancer patients (recurrence and time to death). Modified transfusion practice (e.g,, washing vs. no washing) may improve outcomes in transfused cancer patients. Basic research is needed as well.
Cancer Immunology & Prevention
Cancer Research Ideas - Cancer Immunology & Prevention (Archived)
In the past few years, the rapidly advancing field of cancer immunology has produced several new methods of treating cancer, called immunotherapies, that increase the strength of a patient’s immune responses against tumors. Such treatments have led to dramatic successes in some cancers but not others. At the same time, the concept of adjusting the immune response, or immunomodulation, is being extended into cancer prevention, with the goal of developing strategies to spur the immune system to both prevent the development of cancer in the first place and prevent recurrence.
The submission period for Cancer Immunology & Prevention ideas ended on July 1. However, we encourage you to sign up for regular e-mail updates about the National Cancer Moonshot Initiative at the Cancer Moonshot Milestones web page.
TAA-specific viral expression of Flu Ag (e.g. HA) on the surface of cancer cells, and specific killing of those by host anti-Flu Ag antibody and/or Flu Ag-specific host CTLs, which is raised by Flu vaccination.
Immune checkpoint inhibitors (ICIs) works against cancers with many somatic mutations, because immune systems recognizes these as "non-self" antigens. ICI therapy is proposed for former pediatric cancer patients with therapy-induced late cancers.
Combination studies between checkpoint inhibitors and other treatments, ex. Selective Inhibitor of Nuclear Export (SINE™) compounds, could further improve checkpoint inhibitor response rates in cancer patients (Ref. idea #601 for SINE™ compounds).
Isolate patient's own CD8+ T cells, or use HLA matched healthy donor's CD8+ T cells. Shut down the PD-1 expression, and engineer those T cells express mutated PD-1. The mutation site is intracellular which will cause impaired PD-1 signaling pathway.
Investigations and interventions focused on biobehavioral contributors to immune system dysfunction (obesity, smoking, nutritional alterations, physical inactivity, stress).
Novel immunologic approaches, such as hematopoietic stem cell transplant, CAR T-cell therapy, and checkpoint blockade strategies show great curative potential in their application and treatment of malignant hematologic diseases.
Exosomes could help in solving greatest mysteries of cancer metastatic organotropism. Exosomes have a great potential not only as for cancer cure and early cancer prevention but also it is a novel avenue to understand cancer behavior.
$25 million NTP Study shows wireless radiation causes cancer subthermally while our safety standards only protect thermal effects. We want a mtg w VP Biden our scientists have mechanism how RF Radiation causes cancer. Keephealthyfamilies@gmail.com
We published two books about oncology immunotherapy:
New concept and new way of treatment of cancer
On Innovation of treatment of cancer
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A Placenta Suspension (Filatov) has shown humoral and Th1 T cell immune responses in women with genital cancers that highlights an immune crossreactivity between class II MHC tumor reactive helper peptides and class II MHC binding placental peptides
Monoclonal antibodies are taking the field of cancer and immunotherapy by storm, but limitations in terms of pharmaco-economics, -kinetics & efficacy remain. Our DNA approach addresses these issues by turning the patient into the medicine producer.
The link between obesity and cancer is well established, yet much of public health research focuses on the linking obesity to CVD. More studies that educate the public about the cancer-related risk of diet, nutrition, and obesity are needed.
Tumors must acquire ability to evade detection and killing by immune system. Finding early makers of immune decline/ immunosuppression and applying those in the context of populations 'at risk' for cancer could be a powerful early diagnostic tool.
Oral squamous cell carcinoma (OSCC) accounts for the majority of head and neck cancers. We showed that Lysine-specific demethylase 1 (LSD1) is epigentic regulator and aberrant regulation leads to cancer progression.