Using radiation as the medium to quantitatively deliver energy to a subvolume for drug release and tissue probing.
Cancer Research Ideas - Implementation Sciences (Archived)
Studying the impact of cancer on large populations can provide important information that influences practices, policies, and programs that directly affect the health of millions of people each year. To improve cancer outcomes, it is essential to identify and test methods for more effectively disseminating information about new approaches for cancer prevention, risk assessment, screening, prognosis, treatment, and survivorship. Interventions must fit within real-world public health and clinical settings and be accessible and understandable to practitioners and the public.
The submission period for Implementation Sciences ideas ended on July 1. However, we encourage you to sign up for regular e-mail updates about the National Cancer Moonshot Initiative at the Cancer Moonshot Milestones web page.
Existing data from cancer epidemiology cohorts is not being analyzed; new cohorts are very difficult to initiate with NIH funding.
Society of Gynecologic Oncology recommends that patients have germline genetic testing for appropriate cancers (breast, ovary, colon) within 8 weeks of diagnosis, and that cascade testing be enhanced.
Cancer Systems Therapy: a psychosocial-physiological adjunct systemic protocol as an integral component of medical treatment for increased immune system response.
The immune system *almost* destroys cancers. Bone marrow transplants to force systemic host/graft have proven effective, but with obvious downsides. If we understood how NKLs decide to kill a little better, we could do a subtler version of this.
1) Sequence both healthy and cancerous tissue
2) Find consistent difference
3) Make CRISPR to insert cytotoxin at the difference
4) Deliver CRISPR into cells [hard]
Mature cancer cells of different types have dimensions and characteristics that separate them from normal cells. This can be done by using nano-size machines that fit in areas where differences occur and attach themselves causing cancer cell death.
Researchers can leverage Open Science platforms to collaborate with colleagues from around the world. For these platforms to be useful for researchers, they should be easy to use, web-accessible and should not require advanced programming knowledge.
ASCO is pleased to submit this Cancer Moonshot idea: Population-Wide Implementation of Evidence-Based Cancer Prevention.
Use of mHealth technology to support patient and/or caregiver(s) ability to self-manage medication adherence and symptoms so that treatment can be administered as prescribed.
Oncology social workers are critical to the successful implementation of cancer treatment. They work with patients and families to insure that recommended treatments are implemented. A PBRN is needed to identify the most effective practices in OSW
Low rates of adoption of guideline-endorsed somatic and germline genomic testing leads to poor quality care. Implementation science interventions to improve test utilization in routine care will enhance efforts in cancer prevention and treatment.
Researchers might use CRISPR/Cas9 and C2c2 to edit and correct mutations in genes p53, RAS, KRAS, EGFR and others.
Use nanoparticles, antibodies and toxins to inhibit protein synthesis and induce apoptosis in cancer cells, using streptomycin, neomycin, kanamycin, gentamycin, chloramphenicol, erythromycin, cycloheximide, corynebacterium diphtheria, and ricin.
Optimum health is impacted by policies, systems and environments (PSE). Work in cancer prevention and control must include implementing PSE change approaches in order to effectively improve health and lower cancer incidence in communities.