There are several new FDA-approved immunotherapies available. However, patterns of use, management of side effects, and patient response in real-world clinical settings are currently unknown. Implementation and effectiveness studies are critical.
Cancer Research Ideas - Implementation Sciences (Archived)
Studying the impact of cancer on large populations can provide important information that influences practices, policies, and programs that directly affect the health of millions of people each year. To improve cancer outcomes, it is essential to identify and test methods for more effectively disseminating information about new approaches for cancer prevention, risk assessment, screening, prognosis, treatment, and survivorship. Interventions must fit within real-world public health and clinical settings and be accessible and understandable to practitioners and the public.
The submission period for Implementation Sciences ideas ended on July 1. However, we encourage you to sign up for regular e-mail updates about the National Cancer Moonshot Initiative at the Cancer Moonshot Milestones web page.
Much of the cancer burden is preventable by focusing on known risk factors such as tobacco use, physical inactivity, and unhealthy eating. Numerous authoritative sources provide an array of evidence-based interventions (EBIs) to prevent cancer.
Healthcare for the 15 million (and growing) US cancer survivors is often poor, resulting in poor outcomes and high costs. Implementation research is needed to optimize survivorship care plans, which have been proposed to improve survivors’ care.
Upon death, all persons would have their DNA sequenced. Information is gathered in exactly the same ratios as current causes of death. Genomic links to causes of death can be investigated.
A plan for oncologists was created to implement HRQOL assessment into practice as a primary objective. The primary objective focuses on ongoing assessment of: perceived self-efficacy, supports, and coping for cancer survivors.
Evidence suggests aspirin is useful in preventing some cancers, including colorectal cancer.
Cancers often exhibit one particular pattern of mutagenesis more than others. For example, chromosome instability vs. microsatellite instability vs. hyper-recombination vs. methylation changes. Customize chemotherapy based on these patterns.
Gentamicin is a read-through agent that suppresses nonsense mutations. However, gentamicin is almost always added to cancer cell lines during experiments to prevent contamination. But read-through of nonsense mutations alters cancer experiments.
Pseudogenes are cDNA copies of expressed genes that have integrated into the human genome via retro-transposition from LINE-1 transposable elements. Because the LINE-1 elements activate in some cancers, those cancers may have more pseudogenes.
Radioactive thymidine incorporation in predictive assay can be used to measure inactivation of malignant cells with an agent tailored to a particular type of tumor.
Cancer immunotherapy: simply cell biology? Trends Mol Med. 2003 Dec;9(12):515-6.
Idea to accelerate access to evidence-based cancer prevention intervention among immigrant and minority populations.
In spite of consensus suggesting staging imaging for incident prostate cancer is obsolete, almost half of men with incident disease undergo inappropriate imaging. We propose a clinical trial of an intervention to improve guideline-concordant imaging.
Because quality of care for diagnosed patients with colorectal cancer varies between hospitals, quality assessment and quality improvement programs should be established, utilizing audit and feedback, stakeholder engagement, and checklists.
Community-based organizations have limited capacity to use evidence-based programs, which limits their impact on population health and health disparities. Capacity-building initiatives offer an opportunity to address this important gap,