Prevention programs that have improved cervical cancer rates in developed countries are not feasible in low-resource settings. A strategy that consists of low-cost HPV testing combined with immediate treatment would be highly effective.
Cancer Research Ideas - Implementation Sciences (Archived)
Studying the impact of cancer on large populations can provide important information that influences practices, policies, and programs that directly affect the health of millions of people each year. To improve cancer outcomes, it is essential to identify and test methods for more effectively disseminating information about new approaches for cancer prevention, risk assessment, screening, prognosis, treatment, and survivorship. Interventions must fit within real-world public health and clinical settings and be accessible and understandable to practitioners and the public.
The submission period for Implementation Sciences ideas ended on July 1. However, we encourage you to sign up for regular e-mail updates about the National Cancer Moonshot Initiative at the Cancer Moonshot Milestones web page.
Using a standardized tumor scoring system that takes into account a critical event during cancer – immune cell infiltration – can assess: 1) survival outcomes of cancer, 2) predict therapeutic response, and 3) inform therapeutic regimens.
Many countries have recently enacted screening programs for cervical cancer; however, even the most effective screening program will fail if treatment is not accessible This project proposes a low-cost, portable, durable treatment solution.
Using radiation as the medium to quantitatively deliver energy to a subvolume for drug release and tissue probing.
Existing data from cancer epidemiology cohorts is not being analyzed; new cohorts are very difficult to initiate with NIH funding.
Society of Gynecologic Oncology recommends that patients have germline genetic testing for appropriate cancers (breast, ovary, colon) within 8 weeks of diagnosis, and that cascade testing be enhanced.
Cancer Systems Therapy: a psychosocial-physiological adjunct systemic protocol as an integral component of medical treatment for increased immune system response.
The immune system *almost* destroys cancers. Bone marrow transplants to force systemic host/graft have proven effective, but with obvious downsides. If we understood how NKLs decide to kill a little better, we could do a subtler version of this.
1) Sequence both healthy and cancerous tissue
2) Find consistent difference
3) Make CRISPR to insert cytotoxin at the difference
4) Deliver CRISPR into cells [hard]
Mature cancer cells of different types have dimensions and characteristics that separate them from normal cells. This can be done by using nano-size machines that fit in areas where differences occur and attach themselves causing cancer cell death.
Researchers can leverage Open Science platforms to collaborate with colleagues from around the world. For these platforms to be useful for researchers, they should be easy to use, web-accessible and should not require advanced programming knowledge.
ASCO is pleased to submit this Cancer Moonshot idea: Population-Wide Implementation of Evidence-Based Cancer Prevention.