Cancer genomics papers in Science, Nature, and elsewhere show marrow and brain tumors exhibit lower mutation rates than in stiffer tissues such as lung and skin. In childhood cancers, Chromosome # changes are also greatest in bone and muscle cancer.
Tumor Evolution & Progression
Cancer Research Ideas - Tumor Evolution & Progression (Archived)
Cancer genomics has yielded a greater understanding of the mutations that occur within cancer cells and their roles in tumor initiation and progression. Concurrent with an increased understanding of cancer genomics, a greater appreciation has developed for the enormous heterogeneity of cancer cells that evolve within a tumor, the metabolic changes in both the cancer cell and immune cells in the microenvironment, and the roles of the non-cancer cellular and molecular components of the tumor microenvironment that both support and suppress tumor progression.
The submission period for Tumor Evolution & Progression ideas ended on July 1. However, we encourage you to sign up for regular e-mail updates about the National Cancer Moonshot Initiative at the Cancer Moonshot Milestones web page.
Use model organisms (worms, flies, fish, iPSC organoids) to build models—through standard cloning means—each modeling a patient early and late. All mutations go in.
Laminil is a mast cell stabilizer formulation that inhibits the stress and cell immune response of cancer and halts metastasis or the spread of cancer.
All strong indicators and components of cancer are linked to the Mast Cell
Research shows evolutionary principles can be exploited to prolong tumor control in breast cancer patients. (See article attached.) Clinical trials (CT) to validate this approach are needed & especially crucial for metastatic breast cancer patients.
Personalized cancer therapy approaches enable effective use of targeted therapies based on patients' genomic data; however, these cancer therapies are short lived due to the emergence of resistance—an understudied and clinically relevant phenomenon.
The prognostic significance of the cancer stem cells marker (aldehyde dehydrogenase type I [ALDH1]) expression with breast cancer patients.
In 1983, Barbara McClintock won the Nobel in Physiology/Medicine for discovering that DNA segments can move within the genome ("mobile DNA"). Although most of the millions of copies of mobile DNA are inactive, the active elements cause cancer.
Cancer develops via mutations of healthy DNA. When somebody's kidneys stop working, they are hooked up to a machine to filter their blood for them, a process known as dialysis. Perhaps dialysis machines could be improved to remove cancerous cells.
People who have allergies to certain fruits such as strawberries, mango, pineapple may be missing key nutrients that make them susceptible to developing certain cancers such as breast cancer.
Radiotherapy is rapidly becoming a recognized potential adjunct to immunotherapy (and vice versa) given the potential for non-invasive local treatment of tumor, with synergistic enhancement of antigen presentation.
While advances in imaging technology have greatly improved our ability to visualize the extent of malignant diseases, it is still often difficult to delineate the full extent of primary and metastatic cancer involvement.
Radiogenomics is the study of the link between germ line genotypic variations and the large clinical variability observed in response to radiation therapy. Reproducible associations among SNPs predicting radiation response have been elusive.
Causa do tumor
Most cancer therapeutic targets are currently identified based on cancer genome alterations. We need to redefine actionable cancer targets by implementing large-scale functional genomics screens to identify new cancer soft spots.
Since cancer is an evolution-like disease, all grant applicants who aim to cure cancer must be required to prove how their approach would tackle the problem of cancer evolution. It is not adequate to place this idea in a separate box.