Tumor Evolution & Progression

Cancer Research Ideas - Tumor Evolution & Progression (Archived)

Cancer genomics has yielded a greater understanding of the mutations that occur within cancer cells and their roles in tumor initiation and progression. Concurrent with an increased understanding of cancer genomics, a greater appreciation has developed for the enormous heterogeneity of cancer cells that evolve within a tumor, the metabolic changes in both the cancer cell and immune cells in the microenvironment, and the roles of the non-cancer cellular and molecular components of the tumor microenvironment that both support and suppress tumor progression.

The submission period for Tumor Evolution & Progression ideas ended on July 1. However, we encourage you to sign up for regular e-mail updates about the National Cancer Moonshot Initiative at the Cancer Moonshot Milestones web page.

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Tumor Evolution & Progression

The deadly minority

Unfortunately, in most patients, it is a minority of drug-resistant tumor cells that are present but not detected at diagnosis (or that evolve) that kill patients. No 'omics technology is good enough at single cell analysis to solve this problem.


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