Increase funding and research focus into what causes cancer to become metastatic. Create NCI working group and SPOREs for metastatic cancer and research metastases across solid tumor types.
Tumor Evolution & Progression
Cancer Research Ideas - Tumor Evolution & Progression (Archived)
Cancer genomics has yielded a greater understanding of the mutations that occur within cancer cells and their roles in tumor initiation and progression. Concurrent with an increased understanding of cancer genomics, a greater appreciation has developed for the enormous heterogeneity of cancer cells that evolve within a tumor, the metabolic changes in both the cancer cell and immune cells in the microenvironment, and the roles of the non-cancer cellular and molecular components of the tumor microenvironment that both support and suppress tumor progression.
The submission period for Tumor Evolution & Progression ideas ended on July 1. However, we encourage you to sign up for regular e-mail updates about the National Cancer Moonshot Initiative at the Cancer Moonshot Milestones web page.
Cancer cells can reverse cell death process & harbor damaged DNA by undergoing anastasis(Greek:rising to life). We propose to cure cancer by targeting anastasis to prevent survival of the damaged cells responsible for cancer recurrence & progression.
Using a combination of 2-DG (2-Deoxy-D-glucose) and fenofibrate effectively exploits 2 universal cancer traits - increased glucose uptake and increased stress - to effectively target the entire tumor, paving the way for a universal cancer treatment.
Many cancer cohorts collect biospecimens, but these samples are usually collected infrequently, making it impossible to correlate these biomarkers with tumor development.
Given funding, OncoPharmacia is ready to go full blast to the moon to create a better cancer chemotherapeutic to attack resistant cancer cells while providing a novel self-destruction mechanism in normal cells that will reduce human suffering.
Identification of new small molecules that have the potential to improve the prognosis of patients with malignant brain cancers will represent a novel approach to cancer treatment. Brain penetrable kinase inhibitor represent a potential solution.
The ideas presented in this research idea are aimed better understanding and treating metastatic cancer across all types of cancer.
Cancer is viewed as a disease of overproliferation, but 90% of patients die due to metastasis. The Achilles heel of metastasis may be its lack of proliferation, presenting a unique opportunity to target this lethal aspect of cancer progression.
Metastatic cells must find a suitable microenvironment to colonize and proliferate in distant organs. Circulating tumor generated exosomes generated might be playing an important role in generating a pre-metastatic niche in the target organs.
Tumor microscopic invasion is not isotropic. Certain microenvironment may be more suitable for the invasion and in turn, the tumor invasion may change the microenvironment. To be able to identify these microenvironment will lead to better treatment.
Lack of knowledge on post-treatment tumor evolution is necessary to predict genetic abnormalities (that tumor will acquire), so dynamically optimized treatment regimens could be given. Emphasis for kinetic over snapshot data collection is needed.
Society of Gynecologic Oncology recommends a coordinated multidisciplinary effort to accelerate drug development against mutated p53 in cancer.