Enrolling patients in clinical trials is expensive and difficult for providers. Creating electronic interfaces that focus on clinical trial information and standardizing them on a national level will cut cost, improve communication and accuracy.
Expanding Clinical Trials
Cancer Research Ideas - Expanding Clinical Trials (Archived)
Cancer clinical trials continue to be the gold standard by which new preventive, treatment, supportive care, and other interventions are tested and compared with existing interventions. New clinical trial designs are emerging with the recognition that a single cancer type may consist of many different molecular subtypes and that a given molecular alteration may drive many different types of cancer. At the same time, it is important that more patients have the opportunity to enroll in trials, to ensure that the results of trials are as broadly applicable as possible and that answers are obtained as quickly as possible.
The submission period for Expanding Clinical Trial ideas ended on July 1. However, we encourage you to sign up for regular e-mail updates about the National Cancer Moonshot Initiative at the Cancer Moonshot Milestones web page.
Most genetic mice used now only represent familial versions of disease, if they are developed with a mutation.
HAMLET is effective against for example brain tumors (glioblastoma), bladder cancer and colon cancer. HAMLET has killed many different types of tumor cells in vitro and in animal models. Effect has been seen in humans. It has no known side effects.
A new paradigm for gynecologic cancer clinical trials would involve umbrella trials with adaptive trials designs. Results: Reduce barriers to opening new trials; increase availability and flexibility; increase enrollment; more rapid clinical advances
There has been decades of research on candidate drugs from herbs that never make it to clinical trial. Triptolide has been shown to be effective on all NIH lines of cancer cells, and several others. And modern drug design should be utilized.
ChemoID diagnostic assay assists oncologists in optimizing cancer therapy for their patients by testing standard-of-care chemotherapy drugs against Cancer Stem Cells (CSCs) which are an underlying cause of tumor recurrence and metastasis.
Drug repurposing is an exciting avenue to improve patients’ outcomes. It is a fast, adaptive, cost-effective, safe and de-risked drug development strategy. However, a clear strategy to sort what's benefical for patients from what's not is lacking.
Young adults are the least represented age group in clinical trials. Inadequate trial participation as expected equals inadequate survival benefit for decades,
"Stop Feeding your Cancer" is about patients with brain tumors and some other advanced cancers and how their tumors stabilized and even shrunk on Ornish type diet. T Colin Campbell's work indicates even further benefits from a vegan diet.
There should be greater flexibility as to whether patients need to undergo chemo and radiation before being allowed to participate in clinical trials. This should be a decision between doctor and patient because there are pros and cons to both.
The fed govt has failed to explain their inaction in marijuana research, while countries such as Israel, Spain - even China- are much further ahead in cannabinoid research. Surveillance of, and epidemiological studies on medical cannabis are needed.
ASCO is pleased to submit this Cancer Moonshot idea: Determine Effective Ways to Improve Processes Associated with Conducting and Managing Clinical Trials. Please see the attached document for a more detailed proposal.
ASCO is pleased to submit this Cancer Moonshot idea: Clinical Trial Accrual and the Representativeness of Research Participants.
Genomic profiling of DNA and RNA has provided valuable new insights into the genetic basis of hematologic cancers. Translating this knowledge into meaningful results for patients requires improved patient access to clinical trials for these diseases.
Many prominent scientists believe that a plant based diet, rather than a traditional Western diet, has extensive health benefits. It is time that such a study is undertaken.