Other Exceptional Opportunities

Cancer Research Ideas - Other Exceptional Opportunities (Archived)

Not sure where to enter your idea? Use this space for other ideas you may have that could provide exceptional opportunity for progress, including ways to improve the cancer research process, encourage collaborations, and achieve other goals important to advancing progress against cancer.

The submission period for Other Exceptional Opportunities ideas ended on July 1. However, we encourage you to sign up for regular e-mail updates about the National Cancer Moonshot Initiative at the Cancer Moonshot Milestones web page.

Research Area: Other Exceptional Opportunities

one kind special peach's leaf

Before use this medicine we check the patients blood routine examination.After use this medicine we check the patients blood routine examination.We find all the target of cancer was down. And the patients will not have fever and recover in one month.

Submitted by (@leeleemanyeung)

How will your solution make a difference :

This medicine can work for breast cancer, cancer of stomach.And most patients can control their cancer did not become bad for many years.(Sorry my English not enough for understand.If have translator I can tell more details.)

What is your proposed solution :

We use this kind peach's leaf made medicine and we already help many people recover from many different cancer.

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Research Area: Other Exceptional Opportunities

PG-SGA: Simple, Evidence-Based, Global Impact-Outcomes, Quality

Pres. JFK took something (the moon) integral to everyday life (as is nutrition) and gave voice to a simple idea (a moon landing by decade end) that seemed impossible but gave us a vision that changed the world. PG-SGA+Technology = Cancer Success

Submitted by (@faithotterymdphd)

What is the research problem :

Malnutrition is dreaded by patient, carer, and clinician and impacts both oncologic outcomes and patient quality of life. The question remains: do patients die of their cancer, the complications of their treatment, or associated malnutrition?

How will your solution make a difference :

Integration of proactive PG-SGA (multilingual) with technology will help answer the critical questions above, improve quality of care, patient experience across the cancer continuum and oncologic outcomes and global interdisciplinary collaboration.

What is your proposed solution :

To integrate the gold standard of nutritional assessment, the validated Patient-Generated Subjective Global Assessment (PG-SGA), or its app, in oncology clinical trials, electronic medical records, and Big Data interfaces such as CancerLinQ -- to understand the impact of addressing (or failing to address) simple variables of weight loss, intake, symptoms/impediments and ECOG performance status on patient and oncologic outcomes.

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Research Area: Other Exceptional Opportunities

Physical Sciences and Engineering are essential to progress

While the focus in cancer-related research has been on molecular understanding, engineering approaches can enable the handling of large knowledge, its harnessing for detection, diagnoses and therapy as well as aid quality of life for survivors

Submitted by (@rohitb)

What is the research problem :

How to turn basic cancer knowledge into useful interventions and durable products that can aid in detection, diagnosis, therapy and quality of life for survivors?

How will your solution make a difference :

Engineering can bring solutions at scale and with a cost efficiency and innovation that can provide increased quality of care at lower cost. This can enable a wider benefit to patients, especially those undeserved by present approaches.

What is your proposed solution :

1. Engineering and technology based Cancer Center

2. Educate engineers in cancer applications

3. Multidisciplinary approaches to cancer problems that engage principles from physical sciences

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Research Area: Other Exceptional Opportunities

PG-SGA: Simple, Evidence-Based, Global Impact-Outcomes, Quality

Pres. JFK took something (the moon) integral to everyday life (as is nutrition) and gave voice to a simple idea (a moon landing by decade end) that seemed impossible but gave us a vision that changed the world. PG-SGA+Technology = Cancer Success

Submitted by (@faithotterymdphd)

What is the research problem :

Malnutrition is dreaded by patient, carer, and clinician and impacts both oncologic outcomes and patient quality of life. The question remains: do patients die of their cancer, the complications of their treatment, or associated malnutrition?

How will your solution make a difference :

Integration of proactive PG-SGA (multilingual) with technology will help answer the critical questions above, improve quality of care, patient experience across the cancer continuum and oncologic outcomes and global interdisciplinary collaboration.

What is your proposed solution :

To integrate the gold standard of nutritional assessment, the validated Patient-Generated Subjective Global Assessment (PG-SGA), or its app, in oncology clinical trials, electronic medical records, and Big Data interfaces such as CancerLinQ -- to understand the impact of addressing (or failing to address) simple variables of weight loss, intake, symptoms/impediments and ECOG performance status on patient and oncologic outcomes.

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Research Area: Other Exceptional Opportunities

The Science of Cancer Science Policy

The NCI should fund research on how public policy can accelerate innovation. Currently it funds individual scientific research projects, and research on policy for cancer care delivery, but not big picture analysis of the cancer research enterprise.

Submitted by (@fab.smieliauskas)

What is the research problem :

The Moonshot will address perceived flaws in the cancer research enterprise. But the effects of these problems and of possible solutions on medical innovation are unknown because the NIH does not fund scientific research on cancer science policy.

How will your solution make a difference :

This funded research will answer important questions like: Do precision cancer medicines tested using new clinical trial designs win approval more quickly? Do precompetitive public-private collaborations and data sharing accelerate innovation?

What is your proposed solution :

The NIH already has an Office of Science Policy with a small staff that pursues strategic initiatives on science policy, some of which may relate to cancer. Its grant funding on policy research generally relates to cancer care delivery, not cancer research. To accelerate our understanding of bottlenecks in cancer research, the NCI should create a cancer grant funding stream analogous to NSF's Science of Science and Innovation Policy program.

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Research Area: Other Exceptional Opportunities

Mitochondrial Activation w/Bio-Luminescent Blood - NIR/FIR/Light

Noted previously: DCA & quercetin fight cancer by reactivating mitochondria, causing apoptosis, effects also caused by PQQ & FIR/light. NIMH study shows NIR has similar effect. Bio-luminescent blood w/optogenetic off switch could transmit everywhere.

Submitted by (@ralphcerchione)

What is the research problem :

A means to easily activate mitochondria to induce apoptosis, to be combined w/other non-toxic methods & other treatments. Applications to treating Alzheimer's, Parkinson's & infectious diseases such as AIDS. Adds NIR to FIR/light methods of induction

How will your solution make a difference :

Non-toxic means to wipe out cancer at will w/minimal side effects; possible means of immunization - also potentially curing Alzheimer's/Parkinson's & infectious diseases such as AIDS, particularly w/ultrasound. Most treatments would be very low cost.

What is your proposed solution :

Near-infrared light also reactivates mitochondria, which has applications to Alzheimer's/Parkinson's per NIMH study. Combined w/other methods of reactivation - DCA, quercetin, PQQ, FIR/light & other non-toxic treatments which augment each other. Bio-luminescent blood could carry NIR/FIR/light throughout body w/optogenetic on/off switch. Combining discussed methods could eradicate multiple diseases, or at least halt their progress.

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Research Area: Other Exceptional Opportunities

Cardiac MRI/Biomarkers to Evaluate Injury from Radiation Therapy

The late cardiac effects of radiation therapy are poorly understood. Cardiac-MRI and serum biomarkers could help clarify the mechanisms of cardiac injury, permitting clinicians to better protect the heart using enhanced radiation techniques.

Submitted by (@jsnider)

What is the research problem :

Exposure of the heart to radiotherapy in the standard management of especially lung and breast cancers has been linked to increased long-term risk for cardiac events/morbidity. The etiology/mechanism for this damage remains unclear.

How will your solution make a difference :

Data garnered from Cardiac MRI and biomarker testing could help guide treatment planning to reduce the long-term cardiac effects of radiotherapy. This could potentially affect the care of millions of patients worldwide annually.

What is your proposed solution :

Cardiac MRI has shown the capability to provide quantitative metrics of cardiac function and injury, while serum biomarkers remain some of the most effective and useful tests in the diagnosis and monitoring of heart damage/failure. These low-risk tests would be utilized before and after radiation therapy to elucidate the regions/extent of injury and to correlate these with radiotherapy dose to various substructures of the heart.

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Research Area: Other Exceptional Opportunities

Best practices to reduce childhood Leukemia from ELF EMF

Institute the known low to no cost Precautionary Best Practices to fix Extremely Low Frequency EMFs exceeding 2mG in all school, residential and commercial building new construction and modernizations.

Submitted by (@antoinette.stein)

What is the research problem :

Childhood Leukemia and adult brain tumors from possible carcinogenic exposures to Extremely Low Frequency EMF radiation in buildings

How will your solution make a difference :

The science based evidence shows that such exposures are possible carcinogenic exposures therefore mitigating them will reduce risks at no to low cost- childhood leukemia is the #1 cancer for children addressing it is worthwhile!

What is your proposed solution :

Work to provide building facility training to measure and repair all ELF EMF exposure levels at or above 2 mG in all school, residential and commercial building new construction and modernizations from NET CRRENTS that are mis-wiring NEC code violations.

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Research Area: Other Exceptional Opportunities

Accelerating Clinical Trials’ reporting of CIPN Data (ACT-CIPN)

Chemotherapy-induced peripheral neuropathy is a potentially debilitating form of nerve damage caused by cancer treatment. Clinical trials are required to report the most serious CIPN, but data on less severe symptoms is not publically available.

Submitted by

What is the research problem :

Despite decades of research, the full incidence of CIPN is poorly defined. New research suggests that even less severe CIPN can impact quality of life and daily function, but open-access to this data is a problem.

How will your solution make a difference :

An open-platform dataset would shed light on the true incidence of CIPN. More complete data would help us understand the impact of mild to moderate CIPN on areas such as survivors' occupational funcitonal and quality of life.

What is your proposed solution :

Create an open-platform hub for the sharing clinical trial data on CIPN that includes all levels (grades I-IV) of neuropathy. Where possible, this dataset should include relevant quality of life, occupational, and functional characteristics about patients.

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Research Area: Other Exceptional Opportunities

Identifying Nursing-Usable Screening Tools for CIPN

Chemotherapy-induced peripheral neuropathy is a toxicity associated with cancer treatment. Early detection methods for CIPN are needed. In addition, nurses who perform the majority of CIPN screening are often not involved in the R&D process.

Submitted by

What is the research problem :

Technologies that can detect early signs of CIPN (including the most debilitating CIPN) are urgently needed. To be cost-effective and have high-uptake, this research needs to include the nurses that will perform the majority of these tests.

How will your solution make a difference :

In the absence of treatments for CIPN, early detection is critical to minimizing long-term morbidity in survivors. Harnessing nurses' expertise will be vital to identifying viable early detection that are likely to be used in routine practice.

What is your proposed solution :

Convene an expert panel of researchers, nurses, physicians, pharmacists, neurologists and engineers to (1) identify promising early detection methods for CIPN; (2) get input from nurses on the characteristics that would be needed to make these potential screening tools useful in practice, (3) disseminate these findings, (4) use these findings to fast-track development/testing of these tools.

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Research Area: Other Exceptional Opportunities

Radiogel Y-90 Device can help companion animal cancer patients

We need help to accelerate the use of Radiogel Y-90 Device. It is a uniquely safe isotope delivery device that can help companion animal cancer patients while they serve as a model that can be translated rapidly to help human cancer patients.

Submitted by (@smartbullets)

What is the research problem :

Inoperable malignant tumors are difficult to manage and their fatal agenda kills people and companion animals every day.

We need help with 5 items in the attachment below to accelerate the use of Radiogel Y-90 Device.

See attachment!

How will your solution make a difference :

Radiogel reduces tumors without surgery. There are no adverse events for patients to endure while tumors undergo shrinkage and a second treatment can be given if needed. Radiogel will spare cancer patients with inoperable tumors. See attachment

What is your proposed solution :

Radiogel is a novel combination of Yttrium-90 (Y-90) isotope and a polymer, which can be injected into tumors using a fine needle. The cancer patient's body temperature initiates a phase transfer that entraps the isotope within the tumor. Y-90 is a beta emitter with a short half life of 2.7 days. Radiogel Y-90 device provides a new, practical and significantly less expensive, more effective resorbable localized therapy.

See attachment

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Research Area: Other Exceptional Opportunities

Prevention: Healthy School Environments With Safe Technology

Currently schools are investing in Wi-Fi networks and encouraging cell phone use by children in classrooms. Teachers are also using virtual reality systems in classrooms whereby a Smartphone is placed in cardboard and positioned at children's eyes.

Submitted by (@devradavis)

What is the research problem :

Virtual reality exposes the eyes and brain to close range microwave radiation. Phones were never tested in such positions. Research shows the eyes are most vulnerable to this radiation. Effects could include increased cancer as well as blindness.

How will your solution make a difference :

Schools need state of the art 21st century technology but we need it to be safe for children. A transmitting smartphone to the eyes of children in classrooms with virtual reality is not healthy.

Children need safe/healthy technology tools.

What is your proposed solution :

Before schools roll out such technology, research should be done to understand the effects of this radiation on a child's developing eye and brain.

 

Furthermore, there is no research that considers the current electromagnetic radiation environment in schools. Between the virtual reality systems and the cell phones/Wi-Fi, the exposures are unprecedented. Exposure should be reduced until studies are done to characterize the risk and environment.

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