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Can cancerincidence be reduced by optimizing D-vitamin-levels?

I have heard that there is a correlation between life-expectancy and levels of D-vitamin. Is there a correlation between D-vitamin and cancer? Are certain types of cancer more rare among people that has optimal levels of D-vitamin?

What is the research problem

I don´t know enough about details concerning D-vitamin´s effects in the body and on cancer specifically. I have heard that D-vitamin helps protect against infection and that people that has low or high D-vitamin levels in general live shorter lifes.

How will your solution make a difference

If there is a correelation between levels of D-vitamin and cancer the D-vitamin levels should be monitored and D-vitamin supplementation given to those who need it. Hopefully this has some effect on cancerincidens.

What is your proposed solution

Study if there is a correlation between cancer and D-vitamin levels. Which people benefit from getting D-vitamin supplementation in the USA? All Children up to 2 years of age should get D-vitamin supplementation,, people with dark skin probably need supplementation regardless of the age if they live in North America.

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Can tattooes cause cancer?

I have heard that color/tattoo pigment can be seen in the bonemarrow if a person recently has made a tattoo. What are the consequenses of this on cells in the bonemarrow, lymfnodes, spleen, liver and in the skin/dermis?

What is the research problem

Tattoos are common but not enough is known about their effects in the human body, particularly in the skin, lymfnode, spleen, bonemarrow and liver. Do tattoos cause cancer?

How will your solution make a difference

Increased knowledge about sideffects of tattoos could lead to better information to the public and hopefully a lower incidense of cancer.

What is your proposed solution

More epidemiological, big data, studies should be done to see if there is any relationship between prevalence of tattoos and cancer in for example bonemarrow/lymfnode/hematologic cancer and skincancer. I guess that a relationship between tattoos and cancer can be seen.

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Web-based Platform for Collaborative Research on Treating Cancer

Treating cancer calls for a critical balance between the efficacy of the drugs and their side effects from toxicity, which is patient-specific. Implementing requires quantitative understanding through mathematical models of patient background.

What is the research problem

Employ quantitative understanding of phenotypic behavior of cancer patients to negotiate treatment efficacy with control of toxicity by rational adjustment of drug dosage. This involves collaboration between engineers and clinicians.

How will your solution make a difference

Because of the dire necessity for teamwork among engineers, bioscientists, clinicians and mathematicians, the proposed web base create a vibrant atmosphere of collaboration leading to the rapid progress that is needed in this area.

What is your proposed solution

Create a web based platform with information on research groups working on a particular drug/disease to facilitate active collaboration between computational and experimental research groups. This platform must include clinical data badly needed for extracting patient specific parameters from models that combine traditional PK-PD models with understanding of cellular metabolism. This work will lead to usable Apps for clinical practice.

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Distress Screening and Follow up Care in Clinical Trials

To help ensure the highest level of care is provided, and to further reduce cost, CSC requests that the NCI make an investment to research psychosocial and behavioral health components affecting cancer patients.

What is the research problem

Despite data showing improved patient outcomes and reduced cost, cancer patients are not guaranteed distress screening and follow up care when enrolled in a clinical trial. Leading to inefficiencies and low retention rates.

How will your solution make a difference

Patients have better health outcomes when screened and treated for distress. Routine distress screening and follow up care in clinical trials, will lead to more efficient use of clinical trial resources and have positive impact on patient outcomes.

What is your proposed solution

We propose that the NIH screen patients for distress at the NIH Clinical Center and in all NCI-funded clinical trials, and direct the OHRP to develop guidance specific to addressing the psychosocial needs of patients in clinical trials research. Also, implementation of a pilot study funded by the NCI and NIH, to measure the impact of distress screening and follow up care, on health outcomes and clinical trial participation.

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Bridging innovation and clinical utility through foundational re

Over 80% of cancer clinical trials are null or negative despite promising preclinical results. We are rushing to the clinic without doing the due diligence of fine-tuning the treatment strategy preclinically,

What is the research problem

The lack of resources for essential validation studies with new agents is the primary culprit behind the high rate of null trials. The majority of new agents are tested in experimental conditions that are irrelevant to real-world clinical use.

How will your solution make a difference

Establishment of a new preclinical testing paradigm would thin the herd of futile agents prior to trials thus saving money, resources, and patients from ineffective treatments.

What is your proposed solution

To develop a new testing and validation preclinical paradigm that would allow for uniform evaluation of new agents within the context of the current clinical standard of care. By establishing a reliable set of experimental conditions that closely replicate up-to-date clinical treatments, we would weed out agents and technologies that are incompatible or ineffective in the clinical context prior to onset of clinical trials.

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Create Largest Open-Source, Open-Access Cancer Bio-Repository

80% of cancer patients are treated in community hospitals and clinics. We need a centralized open-source, open-access biorepository managed by brokers with no vested interests other than accelerating the search for cures to help patients today.

What is the research problem

One of the biggest roadblocks to advancing cancer research is access to bio-specimens and patient data. In our community hospitals there are specimens that are used for pathology and then discarded.

How will your solution make a difference

Samples from the community will add statistical power to address questions on molecular subtypes of cancer as we move into the era of precision medicine. Making these bio- and data-repositories open-source & open-access will break down the silos.

What is your proposed solution

80% of all cancer patients are treated in community hospitals and clinics —and tapping into them is critical. These specimens need to be in a centralized open-source, open-access biorepository managed by experienced brokers with the only goal advancing the state of science.This can host bio-specimens from all patients that are well annotated with clinical, pathologic, demographic and outcomes data, and will be a resource to anyone in the field.

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New cohorts to enable precision prevention for cancer

Current cohorts miss critical windows of exposure for understanding cancer development. New cohorts which cover the life course are needed to achieve precision cancer prevention.

What is the research problem

Early life exposures, including infections, contribute to the future development of cancer. We lack knowledge and infrastructure to identify these relationships. Obtaining this information will be important to reduce the burden of cancer.

How will your solution make a difference

New cohorts, with exposure and biospecimens collected in critical windows of risk, will provide needed information for precision cancer prevention.

What is your proposed solution

New population-based cohorts are needed to identify these relationships so that appropriate interventions for the prevention of cancer can occur. This will include rigorous epidemiology, biobanking and links to cancer registries and electronic medical records. A design that capitalizes on family-based enrollment will provide efficiency in both the assessment of genetics, and understanding the connections between microbiome, immunity and cancer.

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Prevention of Negative Heatth Effects 0f Non-Ionizing Radiation

Independent science and the US NTP study have concluded that non-ionizing radiation is indeed causing cancer. Considering wireless radiation surrounds all Americans daily we must tackle this serious issue now with a prevention program.

What is the research problem

We have solid evidence that non-ionizing radiation causes cancer and other serious illnesses (including damage to fetuses) and nothing is being done to prevent this. The public believes our government is protecting them and that is not the case.

How will your solution make a difference

Government advisories concerning lowering exposure to non-ionizing radiation which is an enormous part in all of our lives will indeed help save lives. Children are most vulnerable and there is a long latency period for many of these cancers.

What is your proposed solution

We do not want to eliminate this valuable technology. We want our government to properly oversee the FDA and FCC who are not working in the interest of the public. Measures must be taken now to properly advise the public as to safer ways to use their phones, to turn off wifi when not in use, to use Ethernet in schools, to opt our of smart meters and to keep cell towers away from homes and schools.

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Chemoprevention of lung cancer with Iloprost

In a Phase II trial, Iloprost reduced bronchial epithelial dysplasia. We will conduct a phase IIb/III lung cancer chemoprevention trial with iloprost using the non-invasive LuCED test, instead of bronchoscopy, to facilitate trial recruitment.

What is the research problem

There are currently no effective lung cancer chemoprevention treatments. Patients with dysplasia have no symptoms, so the method of diagnosis needs to be non-invasive. Iloprost treatment will require the LuCED test companion diagnostic.

How will your solution make a difference

Visiongate’s non-invasive LuCED test, capable of dysplasia and cancer detection, will help recruitment into chemoprevention trials. Lung cancer chemoprevention will have an enormous impact on outcomes of the number one cancer killer, lung cancer.

What is your proposed solution

Oral iloprost, a prostacyclin analog, significantly reduced bronchial epithelial dysplasia in a successful phase II clinical trial. LuCED, an automated 3D analysis of individual cells in sputum, enables dysplasia diagnosis without bronchoscopy. In collaboration with the U. Colorado SPORE Lung Cancer Group and the NCI, we will carry out a controlled phase IIB/III clinical trial to confirm that Iloprost reduces dysplasia and lung cancer incidence.

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Defining quality cancer survivorship care for Veterans

Conduct a needs assessment of Veteran cancer survivors in order to better define quality survivorship care for this population and other low health literacy populations.

What is the research problem

Veterans are 3 times as likely to have a cancer diagnosis, with more comorbidities complicating care, and low health literacy. Survivorship can address physical and psychosocial effects of treatment but needs have not been defined in Veterans.

How will your solution make a difference

Identified needs can be used to create guidelines and metrics for quality survivorship care, improving long term outcomes of this unique population. Results may be extrapolated to other low health literacy populations.

What is your proposed solution

Mail a survey to Veterans on cancer registries at VA’s nationwide with questions regarding physical and psychosocial needs after cancer treatment. Results can be compiled to identify common themes and identify ways that the VA and other providers can help to meet the needs of Veterans.

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Promoting Interdisciplinary Team Science in Cancer Research

Numerous projects, including the original moonshot and cancer drug development, demonstrate that interdisciplinary teams working towards a common goal can produce important results that complement those results that individuals produce.

What is the research problem

Academic research incentives in cancer align to recognize and reward only one or two individuals for their contributions to a scientific program. This leads to a systematic disincentive for team science that could add new approaches to fight cancer.

How will your solution make a difference

By promoting an environment that rewards team efforts on an equal footing with the recognition individual research achieves, interdisciplinary approaches to the complex problem of cancer will be encouraged in a way that is unavailable today.

What is your proposed solution

Designate a portion of Moonshot funding for projects led by two or more established principal investigators with complementary expertise. Require institutions receiving this funding to work with Moonshot leadership to develop and implement new rewards for all principal investigators working on teams.

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Arm Physicians with Tools to Address Financial Toxicity

Cancer care costs are rapidly increasing and have negative financial consequences on the patient and economy. Giving physicians tools to screen patients for financial toxicity can help protect patients from financial burdens.

What is the research problem

Over half of 1,067 survivors surveyed by LIVESTRONG faced financial problems as a result of their treatment. Overwhelmingly, they reported not having a conversation with their provider about the costs of their care and its related financial burden.

How will your solution make a difference

Once identified, important steps can mitigate (or prevent) the impact of financial distress such as referrals to financial assistance, switching to less expensive meds, decreasing the number of tests, and decreasing the number of doctor visits.

What is your proposed solution

Evidence based and validated tools can assist physicians to screen patients for financial toxicity. NCI should further assess tools that can help patients and providers anticipate and address the financial strains/concerns/toxicity that can come soon after a diagnosis. NCI should publish recommendations on reviewed and “approved” tools, or alternatively, invest in the development of tools to help meet the need.

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Insurance coverage for cancer patients

Insurance coverage should be mandated to provide coverage for cancer diagnosis and treatment. High out-of-pocket costs, coverage delay and denial all add to the stress of a cancer diagnosis.

What is the research problem

How insurance coverage and perceived problems affects the patient who has been diagnosed with cancer.

How will your solution make a difference

Establishing mandated standard coverage at a federal level can set a standard for insurance coverage for all insurance coverage nation-wide.

What is your proposed solution

May I suggest as part of the Moonshot initiative the Federal Health Insurance Benefit plans be evaluated and redesigned to ensure that cancer patients, who happen to be federal employees, do not have to endure the unnecessary burden of fighting with insurance companies and paying high out-of-pocket expenses that cause additional stress on the family.

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Increase Investments in Cancer Survivorship Research.

Survivorship has become a distinct phase of cancer research. With one-third of the American population facing a cancer diagnosis at some point in their lives, the long-term care of cancer survivors requires more focused attention.

What is the research problem

Due to advances in early detection and treatment, cancer is shifting from acute illness to chronic condition. Health advisory bodies like the IOM have recognized the range of medical, functional and psychosocial challenges facing survivors.

How will your solution make a difference

Increased investments in survivorship research will ultimately improve survivorship care. The number of cancer survivors is expected to rise to 18 million by 2020 according to the CDC, underscoring the need for this research.

What is your proposed solution

According to the most recent figures from the NCI’s Division of Cancer Control and Population Sciences, the NCI funded $61 million in cancer survivorship research in FY 2015. While this figure has steadily increased since 1998, the amount is insufficient compared to the growing number of cancer survivors in the United States.

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