Cancer Research Ideas - Other Exceptional Opportunities (Archived)

Studies indicate that exercise interventions restore a cancer survivors’ physical well-being, mental health and quality of life. Additional research is needed to evaluate the impact of evidence-based community located programs for cancer survivors.

The NCI lacks structure and intellectual capacity to promote outside-the-box (yet scientifically rigorous) ideas despite good intentions. See http://tinyurl.com/gostn3o .

A simple reform of peer-review could unleash enormous innovative potential.

CANScript is an in vitro phenotypic assay that has demonstrated a high clinical correlation across tumor types and drug classes. Expanding its clinical evidence could lead to very high patient response rates and dramatically faster drug development.

Interestingly, ncRNAs constitute more than 90% of the RNAs made from the genome, yet most of the over 20,000 ncRNAs currently known are largely under-studied and under-exploited for Novel Biomarkers and Therapeutics in Cancer.

Oncology drugs have one of the highest failure rates in clinical trials. Investment in and use of modern, human-relevant preclinical test methods will increase translation to the clinic and the likelihood of success of novel new cancer drugs.

My idea is to create International Institute of Oncology with international partnership and participation. Teams of doctors from any country could work there working on new techniques and approaches in fight against cancer.

The increased efficiency of gene disruption or sequence modification enabled by synthetic CRISPR/Cas 9 (RNPs)provides a unique opportunity to increase the sensitivity of transformed cells to standard anticancer therapy in a combinatorial approach.

Optimum nutrition, including use of oral nutritional supplements, improves cancer treatments, course of disease, and health outcomes. Nutrition is often overlooked but is integral for clinical research to accelerate progress in cancer treatment.

NIH funding has led to establishment of sophisticated & complementary genomic tools/technologies run by elite investigators. Talented researchers seeking to solve complex questions could capitalize this consortium & conduct highly quality work.

Medically Tailored Home Delivered Meals (MTHDM) are vital to ensuring cancer patients maintain a healthy and nutritious diet to withstand treatments, improve health outcomes and, in turn, reduce the cost of treatment.

Social media is being leveraged to bring together breast (#bcsm), brain (#btsm), gynecological (#gyncsm), lung (#lcsm), and adolescent and young adult (#ayacsm) cancer communities together on Twitter through hashtags. We must magnify these voices.

Complex oncology patients would have a medical home in a hospital setting that allows them to obtain care for their symptoms on an outpatient basis from familiar providers. The resources of the hospital would be available but the ER avoided.

Oncology often equates inappropriate end of life hospitalization with aggressive management of symptoms in the home environment and dismisses both as ineffective. We need to develop and test models of treatment that improve and prolong life.

To pose some fundamental questions related to clinical trials that emerge with the advent of precision cancer therapy and to explore ways in which recent advances in Image Science can offer answers

A multidisciplinary approach will be used to investigate the genetic, biological, environmental, and social basis for incidence and outcome differences in Hispanic women