Other Exceptional Opportunities

Cancer Research Ideas - Other Exceptional Opportunities (Archived)

Not sure where to enter your idea? Use this space for other ideas you may have that could provide exceptional opportunity for progress, including ways to improve the cancer research process, encourage collaborations, and achieve other goals important to advancing progress against cancer.

The submission period for Other Exceptional Opportunities ideas ended on July 1. However, we encourage you to sign up for regular e-mail updates about the National Cancer Moonshot Initiative at the Cancer Moonshot Milestones web page.

Research Area: Other Exceptional Opportunities

cLean sLate NED

any singLe feeLing that creates heat for me, stays energeticaLLy within my organ systems a singLe 2d infraction each time, buiLding poLarity against my systems, eventually turning into 3d-disease. so i reaLize how to cooL myseLf then diseasesolved

Submitted by

What is the research problem :

gain reaL data on how my systems heat up based upon my heated feeLings, and track the resuLtant effects of cooLing down

How will your solution make a difference :

the answers to cures aLready exist . just need to get the word out and get the data peopLe demand, and to make the simpLe answers mandated schooL curricuLum so youth can conquer their own disease and soLve this puzzLe once and for aLL . gLadiator me

What is your proposed solution :

obtain expert support in creating a new research project - aiming at the two poLar demographics (young & w/cancer) - to start a baseLine tracking of how i reaLLy am my own gLue and i must exactLy mimic my organ systems and be victorious in maintaining baLance where heat once resided . i have a mobiLe app i am Launching soon and this contains the supporting tooLs (first version) to heLp peopLe gain perspective and Learn how they reaLLy work

Voting

0 votes
Ideate

Research Area: Other Exceptional Opportunities

Imaging genomics/radiogenomics

Imaging genomics/radiogenomics is an emerging field focused on integrating quantitative image features from medical images (e.g. MRI, CT) with molecular data from tissue (e.g. mutations, gene expression, proteomics).

Submitted by (@ogevaert)

What is the research problem :

Predicting diagnosis, prognosis or therapy response is at the core of precision medicine. Much data is being collected for cancer patients, and there is a need to find the multivariate signatures that are predictive of clinical outcomes.

How will your solution make a difference :

By linking quantitative image data with molecular data, we can develop non-invasive biomarkers for diagnosis, prognosis and therapy response. For example, image signatures reflecting EGFR mutation status or a signature for response to immunotherapy.

What is your proposed solution :

Imaging genomics/radiogenomics proposes to take advantage of data that is already being collected in most clinical workflows of cancer patients: medical images (e.g. MRI, CT or PET). Using quantitative image analysis and machine learning algorithms such as deep learning, images can be mined to predict clinical outcomes and molecular characteristics. Imaging genomics proposes to integrate quantitative image data with molecular data of tumors.

Voting

0 votes
Ideate

Research Area: Other Exceptional Opportunities

Historical Perspectives

Not knowing who has done what, I submit that we should gather an extensive review of cancer through history - A Cancer Catalog/Encyclopedia

 

Maybe it would help to connect with the 90+ Study of the oldest old at UC.

Submitted by

What is the research problem :

duplication of efforts; identification of what is already known

How will your solution make a difference :

This should reduce duplication of past efforts and establish a solid database of knowledge as a starting point.

What is your proposed solution :

A Cancer Catalog

I'd like to know if cancer has been around since the beginning of our species or genus? Are there any demographics about cancer showing up at specific times in human history? Are there any demographic patterns known? Do some cultures NOT have cancer?

 

What kinds of studies have already been conducted? Has anyone already catalogued what we do know about cancer? What is unique about people who have never gotten cancer?

Voting

0 votes
Ideate

Research Area: Other Exceptional Opportunities

cancer prevention

To prevent cancer

Use soluble preparation of sulfonamide/dorzolamide.

Daily intake of this drug (1-2 drops in the eye or nose) is safe and would prevent cancer.

Submitted by (@mlerman)

Voting

0 votes
Ideate

Research Area: Other Exceptional Opportunities

Top 100 Targets

Have a forum to discuss top cancer drug targets that discusses the rational for a potentially new therapeutic, including pros and cons. Similarly, have a top"100" set of cancer therapeutics with their pros and cons.

Submitted by (@dweber1006)

How will your solution make a difference :

Scientist can have input into communicating potential solutions and problems with targeting various enzymes and pathways and the public can observe the process.

What is your proposed solution :

In both cases, I suggest having a criteria to have them ordered and what data is needed to make the list. Use a format so the public can follow as well as scientists perhaps not too much different from what is shown in a "consumer reports" and then a more in depth examination for researchers.

Voting

0 votes
Ideate

Research Area: Other Exceptional Opportunities

More Reasearch is Needed for Hormonal Therapy

I am a 10 year breast cancer survivor. I was on Tamoxifen for 3 yrs and 5 yrs of Femara. I have suffered from high calcium levels and high PTH levels in my blood. In addition, I developed Osteopenia. More research is needed in this area.

Submitted by (@breastcancersurvivor)

What is the research problem :

Many breast cancer survivors undergoing hormonal therapy experience high calcium levels in the blood and osetopenia/osteoperosis. More reasearch is needed in this area.

How will your solution make a difference :

Increased productive live. Preserving the bone and avoiding Osteopenia/Osteoperosis is important for a long productive full life.

What is your proposed solution :

Some type of therapy is needed. We need to understand why this is happening.

Voting

0 votes
Ideate

Research Area: Other Exceptional Opportunities

Question: How can my body and brain be repaired?

I have a question, rather than an idea.

 

So, I'm cancer free, have been for 4yrs in November... But my body and my brain have never been 'fixed' or 'repaired'... How can my body and brain be repaired?

Submitted by (@iwilliams9)

What is the research problem :

How do I get 'fixed' or 'repaired

 

I don't want to ever let cancer win, but it has changed me, it defines my life. It seems like it did win, in a way.

How will your solution make a difference :

If I can be helped, wouldn't that open the floodgates for help and repair for other brain cancer survivors?

What is your proposed solution :

Time continues... but I'm still waiting

 

I've done years of PT, OT, and other therapies and excercises...

 

Sure I've come a long way from, post surgery I was wheelchair bound, extreme physical impairment...

Will I ever achieve the former 'level' of post surgery 'ability'?

 

God is good, cancer sucks, life after cancer sucks worse, God is good

Voting

0 votes
Ideate

Research Area: Other Exceptional Opportunities

Carcinogens

There are hundreds, perhaps thousands of KNOWN carcinogens in manufactured products that Americans purchase every day.

Submitted by

What is the research problem :

This is not a research problem. The research has either already been done or is ongoing. This solution is a problem of political will.

How will your solution make a difference :

I think this solution is self-explanatory as to it's benefits to America. What is not self-explanatory is why we have not already done this. This is the litmus test FOR YOURSELVE as to how serious you are about what you are trying to do.

What is your proposed solution :

Here's an opportunity for you to prove that you are DEAD SERIOUS about solving cancer (no pun intended). Work with Congress to create a plan/timeline to either, a) ban the sale of ALL products sold to American consumers containing known carcinogens and/or, b) require all manufacturers of products sold to American consumers to ELIMINATE known carcinogens from their products. I understand, it's a political decision, but it won't cost you anything.

Voting

0 votes
Ideate

Research Area: Other Exceptional Opportunities

Support Basic Research

Too much focus of the NIH is placed upon direct clinical applications. Most of the major scientific breakthroughs in the last century have come from basic research, including most of our advances in understanding cancer.

Submitted by (@kellerman72)

What is the research problem :

Basic scientists are left out in the cold when it comes to finding money to support their research.

How will your solution make a difference :

By strengthening the core of basic scientists in this country, thus making the development of new cancer cures and treatments possible.

What is your proposed solution :

By supporting research on how things work at the molecular level, we identify promising new targets for clinical applications. Indeed most chemotherapeutic strategies used today were first developed based on basic research. The NIH should be supporting more basic science, including those who use model organisms such as yeast and drosophila, which at the molecular level are remarkably similar to ourselves.

Voting

0 votes
Ideate

Research Area: Other Exceptional Opportunities

Wall street

Wall Street shorts

Submitted by (@brandi10)

What is the research problem :

Stop letting Wall Street short these little bio company's It destroys value and can make a good idea company bankrupt.There trials never make it because of greed on Wall Street

What is your proposed solution :

People will invest in a company to help find a cure without the worry traders will ruin it in there game of making money by bashing to drive the stock price down--maybe just maybe this could be the bio co that could come up with a cure.Traders don't care about a cure only about their bottom line----until they get cancer

Voting

0 votes
Ideate

Research Area: Other Exceptional Opportunities

Delivery methods for biologic treatments is essential

It is important to consider the increasingly limited discovery of new drugs for cancer treatment and to realize that biologic treatments may very well be the answer to being able to control cancer and limit its devastating effects, namely metastasis.

Submitted by

What is the research problem :

The research problem is two-fold: the drugs we rely on are not always effective enough, and there is an insufficient amount of research on delivery methods of biologically-based treatments that could be made available to patients.

How will your solution make a difference :

Opening the door to serious consideration of biologic treatments as a complement to drugs would bring about a paradigm shift in the way we think of cancer treatment. Many strong ideas have a great deal of promise, but they are not given a chance.

What is your proposed solution :

Further research into treatments that are biologically-based -- a change that has yet to receive support by those who hold the keys to funding -- is a much needed step in the right direction for efficacious treatments. Cancer recurrence is rooted in the way drugs selectively target certain tumor cells, and could be mitigated by the development of delivery methods that allow well-investigated biologic pathways to be taken advantage of directly.

Voting

0 votes
Ideate

Research Area: Other Exceptional Opportunities

GVHD in the gut, prevention or maybe treatment

I work on a BMT unit and have seen the ravaging effects of GVHD. I was thinking that either breast milk or colostrum could possibly repair or help rebuild flora to match the immune system of the graft?

Submitted by (@majcamacho1)

What is the research problem :

GVHD in the gut after allogenic transplant. It is potentially fatal and decreases quality of life.

How will your solution make a difference :

My thinking is that the breast milk or colostrum would act as a stem cell and ease the immune system attack to the gut. This could save people's lives as well as prevent suffering from this issue.

What is your proposed solution :

Give breast milk to patients after transplant to rebuild gut flora.

Voting

0 votes
Ideate