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cLean sLate NED

any singLe feeLing that creates heat for me, stays energeticaLLy within my organ systems a singLe 2d infraction each time, buiLding poLarity against my systems, eventually turning into 3d-disease. so i reaLize how to cooL myseLf then diseasesolved

What is the research problem

gain reaL data on how my systems heat up based upon my heated feeLings, and track the resuLtant effects of cooLing down

How will your solution make a difference

the answers to cures aLready exist . just need to get the word out and get the data peopLe demand, and to make the simpLe answers mandated schooL curricuLum so youth can conquer their own disease and soLve this puzzLe once and for aLL . gLadiator me

What is your proposed solution

obtain expert support in creating a new research project - aiming at the two poLar demographics (young & w/cancer) - to start a baseLine tracking of how i reaLLy am my own gLue and i must exactLy mimic my organ systems and be victorious in maintaining baLance where heat once resided . i have a mobiLe app i am Launching soon and this contains the supporting tooLs (first version) to heLp peopLe gain perspective and Learn how they reaLLy work

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Imaging genomics/radiogenomics

Imaging genomics/radiogenomics is an emerging field focused on integrating quantitative image features from medical images (e.g. MRI, CT) with molecular data from tissue (e.g. mutations, gene expression, proteomics).

What is the research problem

Predicting diagnosis, prognosis or therapy response is at the core of precision medicine. Much data is being collected for cancer patients, and there is a need to find the multivariate signatures that are predictive of clinical outcomes.

How will your solution make a difference

By linking quantitative image data with molecular data, we can develop non-invasive biomarkers for diagnosis, prognosis and therapy response. For example, image signatures reflecting EGFR mutation status or a signature for response to immunotherapy.

What is your proposed solution

Imaging genomics/radiogenomics proposes to take advantage of data that is already being collected in most clinical workflows of cancer patients: medical images (e.g. MRI, CT or PET). Using quantitative image analysis and machine learning algorithms such as deep learning, images can be mined to predict clinical outcomes and molecular characteristics. Imaging genomics proposes to integrate quantitative image data with molecular data of tumors.

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Historical Perspectives

Not knowing who has done what, I submit that we should gather an extensive review of cancer through history - A Cancer Catalog/Encyclopedia

 

Maybe it would help to connect with the 90+ Study of the oldest old at UC.

What is the research problem

duplication of efforts; identification of what is already known

How will your solution make a difference

This should reduce duplication of past efforts and establish a solid database of knowledge as a starting point.

What is your proposed solution

A Cancer Catalog
I'd like to know if cancer has been around since the beginning of our species or genus? Are there any demographics about cancer showing up at specific times in human history? Are there any demographic patterns known? Do some cultures NOT have cancer?

What kinds of studies have already been conducted? Has anyone already catalogued what we do know about cancer? What is unique about people who have never gotten cancer?

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Top 100 Targets

Have a forum to discuss top cancer drug targets that discusses the rational for a potentially new therapeutic, including pros and cons. Similarly, have a top"100" set of cancer therapeutics with their pros and cons.

How will your solution make a difference

Scientist can have input into communicating potential solutions and problems with targeting various enzymes and pathways and the public can observe the process.

What is your proposed solution

In both cases, I suggest having a criteria to have them ordered and what data is needed to make the list. Use a format so the public can follow as well as scientists perhaps not too much different from what is shown in a "consumer reports" and then a more in depth examination for researchers.

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More Reasearch is Needed for Hormonal Therapy

I am a 10 year breast cancer survivor. I was on Tamoxifen for 3 yrs and 5 yrs of Femara. I have suffered from high calcium levels and high PTH levels in my blood. In addition, I developed Osteopenia. More research is needed in this area.

What is the research problem

Many breast cancer survivors undergoing hormonal therapy experience high calcium levels in the blood and osetopenia/osteoperosis. More reasearch is needed in this area.

How will your solution make a difference

Increased productive live. Preserving the bone and avoiding Osteopenia/Osteoperosis is important for a long productive full life.

What is your proposed solution

Some type of therapy is needed. We need to understand why this is happening.

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Question: How can my body and brain be repaired?

I have a question, rather than an idea.

 

So, I'm cancer free, have been for 4yrs in November... But my body and my brain have never been 'fixed' or 'repaired'... How can my body and brain be repaired?

What is the research problem

How do I get 'fixed' or 'repaired

I don't want to ever let cancer win, but it has changed me, it defines my life. It seems like it did win, in a way.

How will your solution make a difference

If I can be helped, wouldn't that open the floodgates for help and repair for other brain cancer survivors?

What is your proposed solution

Time continues... but I'm still waiting

I've done years of PT, OT, and other therapies and excercises...

Sure I've come a long way from, post surgery I was wheelchair bound, extreme physical impairment...
Will I ever achieve the former 'level' of post surgery 'ability'?

God is good, cancer sucks, life after cancer sucks worse, God is good

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Carcinogens

There are hundreds, perhaps thousands of KNOWN carcinogens in manufactured products that Americans purchase every day.

What is the research problem

This is not a research problem. The research has either already been done or is ongoing. This solution is a problem of political will.

How will your solution make a difference

I think this solution is self-explanatory as to it's benefits to America. What is not self-explanatory is why we have not already done this. This is the litmus test FOR YOURSELVE as to how serious you are about what you are trying to do.

What is your proposed solution

Here's an opportunity for you to prove that you are DEAD SERIOUS about solving cancer (no pun intended). Work with Congress to create a plan/timeline to either, a) ban the sale of ALL products sold to American consumers containing known carcinogens and/or, b) require all manufacturers of products sold to American consumers to ELIMINATE known carcinogens from their products. I understand, it's a political decision, but it won't cost you anything.

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Support Basic Research

Too much focus of the NIH is placed upon direct clinical applications. Most of the major scientific breakthroughs in the last century have come from basic research, including most of our advances in understanding cancer.

What is the research problem

Basic scientists are left out in the cold when it comes to finding money to support their research.

How will your solution make a difference

By strengthening the core of basic scientists in this country, thus making the development of new cancer cures and treatments possible.

What is your proposed solution

By supporting research on how things work at the molecular level, we identify promising new targets for clinical applications. Indeed most chemotherapeutic strategies used today were first developed based on basic research. The NIH should be supporting more basic science, including those who use model organisms such as yeast and drosophila, which at the molecular level are remarkably similar to ourselves.

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Wall street

Wall Street shorts

What is the research problem

Stop letting Wall Street short these little bio company's It destroys value and can make a good idea company bankrupt.There trials never make it because of greed on Wall Street

What is your proposed solution

People will invest in a company to help find a cure without the worry traders will ruin it in there game of making money by bashing to drive the stock price down--maybe just maybe this could be the bio co that could come up with a cure.Traders don't care about a cure only about their bottom line----until they get cancer

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Delivery methods for biologic treatments is essential

It is important to consider the increasingly limited discovery of new drugs for cancer treatment and to realize that biologic treatments may very well be the answer to being able to control cancer and limit its devastating effects, namely metastasis.

What is the research problem

The research problem is two-fold: the drugs we rely on are not always effective enough, and there is an insufficient amount of research on delivery methods of biologically-based treatments that could be made available to patients.

How will your solution make a difference

Opening the door to serious consideration of biologic treatments as a complement to drugs would bring about a paradigm shift in the way we think of cancer treatment. Many strong ideas have a great deal of promise, but they are not given a chance.

What is your proposed solution

Further research into treatments that are biologically-based -- a change that has yet to receive support by those who hold the keys to funding -- is a much needed step in the right direction for efficacious treatments. Cancer recurrence is rooted in the way drugs selectively target certain tumor cells, and could be mitigated by the development of delivery methods that allow well-investigated biologic pathways to be taken advantage of directly.

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GVHD in the gut, prevention or maybe treatment

I work on a BMT unit and have seen the ravaging effects of GVHD. I was thinking that either breast milk or colostrum could possibly repair or help rebuild flora to match the immune system of the graft?

What is the research problem

GVHD in the gut after allogenic transplant. It is potentially fatal and decreases quality of life.

How will your solution make a difference

My thinking is that the breast milk or colostrum would act as a stem cell and ease the immune system attack to the gut. This could save people's lives as well as prevent suffering from this issue.

What is your proposed solution

Give breast milk to patients after transplant to rebuild gut flora.

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Psychological intervention impacts survival

2 NIH-funded RCTs of a manualized psychological intervention demonstrate survival benefit among breast cancer patients. We need studies to promote understanding of mechanisms specific to these therapies and translation to clinical practice settings.

What is the research problem

Not treating all risk factors that affect survival/ treatment outcomes.

How will your solution make a difference

Preliminary evidence of improved survival (in 2 NIH-funded RCTs) may be confirmed and therapy can then be disseminated to improve survival rates. Timely in context of accreditation standard requiring distress screening and treatment.

What is your proposed solution

Funding for translational research that tests this psychological therapy in real world clinical settings and includes assessment of potential mechanisms and generalizability to other cancer populations beyond breast cancer.

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Palliative Cancer Care

Palliative care refers to care that focuses on quality of life issues for patients with serious physical and emotional symptoms. In addition to improving quality of life, some research also suggests that palliative care may increase survival.

What is the research problem

There are many different models of palliative care services, and more research is needed to determine which models have the greatest impact on quality of life and survival, and for whom.

How will your solution make a difference

This research will contribute to improving quality of life and survival in cancer, having a beneficial impact for patients and their families.

What is your proposed solution

The Moonshot initiative will likely fund several large, prospective trials. To maximize use of funds, add-on studies should randomize patients to different models of palliative care and examine quality of life and survival benefits. Target populations would include advanced lung cancer and intractable GI cancers.

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