Cancer Research Ideas - Precision Prevention & Early Detection (Archived)

Does chemichals measured in blood correlate to different types of cancers? It would be interesting to examine.

Ferritin measured in the blood has two origins. If the ferritin that leaks out from the liver was measured specifically the chances of detecting livercancer/metastasis or hepatocellurdeath would increase compared to only measuring Serum-Ferritin.

Cancer starts with a stalled, or the failure to start, G1 phase of the cell cycle. There are many reasons why this process becomes stalled. Familial cancers fail to start the G1 phase because a mutation prevents it. Adult cancers are stalled G1 phase

By analyzing exhaled volatile organic compounds biomarkers of cancer can be identified. Different patterns of biomarkers could be identified between different groups of patients. The procedure is not invasive and could be used to find lungcancer.

We propose building an AI application to automate and standardize the screening of patients at high risk of developing liver cancer with the goal of making screening highly accessible and thus finding liver cancer before it is symptomatic

Despite advances against other cancers, oral cancer mortality has not improved in 4 decades. Our findings indicate that the oral microbiome increases cancer risk when it is dysregulated, which offers new diagnostic biomarkers and therapeutic targets.

Reinvent screening/early detection by analyzing simple blood tests using multi-level/parameter algorithm & Cancer Differentiation Analysis tech; 30,000 cases confirm CDA identifies16 different cancer types/locations-often before cells form tumors.

Recent research in toxicology, epidemiology and cancer biology strongly indicates that toxic industrial chemicals and pollutants are having a significantly greater impact on the incidence of cancer than previously thought.

Analyze tumor markers in young healthy adults. Repeat testing these individuals when they are middle age and old to dectect significant change in the tumor markers which indicates the need for further examination of the patient to exclude cancer.

With the widespread adoption of Electronic Health Records (EHRs), it is now possible to implement clinical decision support (CDS) tools in practice to deliver cancer screening recommendations leveraging individual patient medical information.

There are new RNA based genetic differences in people that are strong biomarkers of cancer risk, and need additional study in appropriate clinical trials. Such mutations can be modified by lifestyle, and afford a true opportunity for prevention.

Evidence is mounting for adherence to a healthy lifestyle to reduce cancer risk. A healthy lifestyle pattern defined by tobacco use, alcohol intake, BMI, diet quality & physical activity may reduce risk for incident cancer & mortality. CA Thomson

ARR recommendation

Ovarian cancer is recognized for having a dismal prognosis largely because of the lack of an effective early-detection method. Engineering a mechanism that is cost-efficient, quick, and user-friendly is paramount in augmenting survival rates.

Study comparing standard screening and staging techniques (Prostate biopsy) for the detection of prostate cancer to PET/MR in patients with elevated PSA. Accuracy and cost effectiveness would be compared between the two approaches.