Groups are working on deep sequencing to find tiny amounts of circulating biomarkers of early cancer and its malignant potential. Independent validation of these methods is essential to realizing the full potential of such early detection methods.
Precision Prevention & Early Detection
Cancer Research Ideas - Precision Prevention & Early Detection (Archived)
Advances in genomic technologies should lead to improved prevention and early detection strategies. As we develop a better understanding of common genetic variants that are associated with higher or lower risk of certain cancers, we may be able to use that knowledge to identify individuals who may or may not benefit from prevention strategies. And techniques to analyze bits of tumor DNA (and other molecules) that are released into the blood and other body fluids may enable noninvasive screening for very early cancers.
The submission period for Precision Prevention & Early Detection ideas ended on July 1. However, we encourage you to sign up for regular e-mail updates about the National Cancer Moonshot Initiative at the Cancer Moonshot Milestones web page.
Data aggregation techniques are powerful tools to reduce the information burden that is discouraging physicians from utilizing point-of-care equipment in their daily practice.
Colorectal cancer (CRC) subtypes have distinct genotypes and prognoses. Practical clinical laboratory tests to recognize CRC subtypes are needed to allow certain early-stage CRCs to receive consolidation therapy to prevent recurrence and death.
Understanding an inherited predisposition to hematologic malignancies, and how a pre-cancerous condition becomes cancer will allow for early intervention and cancer prevention.
ConquerX develops a minimally invasive blood test that can detect up to 18 types of cancer based on cutting-edge microRNA sensor technology. Our technology approach to cancer diagnostics and screening by leveraging a new class of biomarkers microRNAs
Films can inspire people to protect themselves from HPV related cancers which are completely preventable.
A combination of enrichment and microfiltration of flora from small quantities of fecal sample is proposed for detection of bacteria that could serve as biomarkers for early stage pancreatic cancer.
Looking more closely at late stage diagnosis as a standard measure of population-based progress makes sense.
Access to care and primary and secondary prevention can be addressed in rural communities by creating total quality care practices.
Although pancreatic ductal adenocarcinoma (PDA) is deadly due to the lack of early detection and effective therapies, patients with PDA derived from a precancerous lesion subtype, IPMN, often face better prognosis than those derived from PanIN.
Many studies done WITHIN countries, show better primary care produces earlier detection of cancers such as colorectal cancer, breast cancer, uterine/cervical cancer, and melanoma. The opposite is the case for higher specialist supply.
Prevention of liver cancer begins with education about the importance of the liver, how it can be damaged, and how to protect it from cirrhosis and eventually cancer. Education is lacking in many current recommendations to prevent liver cancer.
Today we are exposed to more chemicals and environmental toxins than we ever have been. Most of these chemicals have never been tested for safety. We need more research on chemical exposure and its impact on cancer.
We are facing an epidemic of indeterminate pulmonary nodules. The management of those is most challenging, morbid and costly. Non-invasive strategies for accurate diagnosis of lung cancer is needed and requires building of a large concerted effort.
Investigate genetic and environmental influences of people with strong cancer risk factors who haven't developed cancer by age 70. Target people with strong hereditary risk (BRCA, Lynch Syndrome, etc.), long term smokers, known sun exposure, etc.