Accelerate trials of car T cell immuotherapy for prostate cancer
Cancer Immunology & Prevention
Cancer Research Ideas - Cancer Immunology & Prevention (Archived)
In the past few years, the rapidly advancing field of cancer immunology has produced several new methods of treating cancer, called immunotherapies, that increase the strength of a patient's immune responses against tumors. Such treatments have led to dramatic successes in some cancers but not others. At the same time, the concept of adjusting the immune response, or immunomodulation, is being extended into cancer prevention, with the goal of developing strategies to spur the immune system to both prevent the development of cancer in the first place and prevent recurrence.
The submission period for Cancer Immunology & Prevention ideas ended on July 1. However, we encourage you to sign up for regular e-mail updates about the National Cancer Moonshot Initiative at the Cancer Moonshot Milestones web page.
We believe that NK cells, like T cells, have the capacity, to be antigen specific specific through the low affinity binding of CD16 to natural antibody or high affinity binding of tri-specific killer engagers (TriKEs) that also proliferate NK cells.
Cancerous tumors have vasculature which allows them to receive nutrients and grow. The body recognizes these tumors as "self" early in the process and allows this support system to grow.
A phase 1 trial of a short course of high dose radiation therapy to an escalating volume of unresectable mesothelioma followed immediately by an anti-PD1 antibody.
The wealthiest people in the world have unique access to vaccines and cures, and go to great lengths to deny the rest of the world these treatments in the interest of profit.
Human papilloma virus can cause cancer. It is well known that vaccination against certain types of HPV reduces the risk of getting cancer.
Down-regulation of (neo)antigens limits the efficacy of immune-checkpoint inhibitors. Interferon-g is a potent stimulator of MHC expression and antigen-presentation. Administration of systemic IFNg may boost checkpoint-inhibitors.
I have heard that dogs can get cancer from being infected with cancercells from their partner while mating. I have heard of families where two individuals die of cancer or of the same type of cancer shortly after eachother. Is this a coincidence?
I have heard that there is a microbiology instrument that from one drop of blood can find traces of over 100 different infections that a person has been exposed to during her lifetime.
The National Toxicology Program finding that rats exposed to radio-frequency (RF) radiation developed increased brain and heart cancer adds to the weight of evidence showing that RF (from cell phones/wi-fi) is carcinogenic. http://goo.gl/4E5Ecq
We need a shift toward a more positive attitude regarding cancer prevention, rather than a focus on treatment alone.
It is 384 400 km to the moon. This trial aims to treat one patient with a personalized cancer vaccine for each kilometer to the moon - by the end of the decade.
What if we just isolated the gene that each strain of cancer is connected to and weeded it out of the gene pool?
Current immune-oncology research is focused on a limited number of checkpoint targets. Identification of new targets that improve the efficacy when combined with approved checkpoint antibodies would represent an important cancer treatment advance.