Cancer Clinical Trials Ideas

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Cancer Immunology & Prevention

Cancer Research Ideas - Cancer Immunology & Prevention (Archived)

In the past few years, the rapidly advancing field of cancer immunology has produced several new methods of treating cancer, called immunotherapies, that increase the strength of a patient’s immune responses against tumors. Such treatments have led to dramatic successes in some cancers but not others. At the same time, the concept of adjusting the immune response, or immunomodulation, is being extended into cancer prevention, with the goal of developing strategies to spur the immune system to both prevent the development of cancer in the first place and prevent recurrence.

The submission period for Cancer Immunology & Prevention ideas ended on July 1. However, we encourage you to sign up for regular e-mail updates about the National Cancer Moonshot Initiative at the Cancer Moonshot Milestones web page.

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Enhanced Data Sharing

Cancer Research Ideas - Enhanced Data Sharing (Archived)

Sharing data among investigators and institutions is essential for building on the cancer research progress made so far, but many barriers to effective sharing exist. Barriers can arise from technological or infrastructural limitations (data are stored on different systems or are generated by different methods, making them incompatible). Poor access or participation can also be a barrier (some data may not be shared, and some researchers may not be able to access or analyze even data that are publicly available).

The submission period for Enhanced Data Sharing ideas ended on July 1. However, we encourage you to sign up for regular e-mail updates about the National Cancer Moonshot Initiative at the Cancer Moonshot Milestones web page.

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Expanding Clinical Trials

Cancer Research Ideas - Expanding Clinical Trials (Archived)

Cancer clinical trials continue to be the gold standard by which new preventive, treatment, supportive care, and other interventions are tested and compared with existing interventions. New clinical trial designs are emerging with the recognition that a single cancer type may consist of many different molecular subtypes and that a given molecular alteration may drive many different types of cancer. At the same time, it is important that more patients have the opportunity to enroll in trials, to ensure that the results of trials are as broadly applicable as possible and that answers are obtained as quickly as possible.

The submission period for Expanding Clinical Trial ideas ended on July 1. However, we encourage you to sign up for regular e-mail updates about the National Cancer Moonshot Initiative at the Cancer Moonshot Milestones web page.

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Implementation Sciences

Cancer Research Ideas - Implementation Sciences (Archived)

Studying the impact of cancer on large populations can provide important information that influences practices, policies, and programs that directly affect the health of millions of people each year. To improve cancer outcomes, it is essential to identify and test methods for more effectively disseminating information about new approaches for cancer prevention, risk assessment, screening, prognosis, treatment, and survivorship. Interventions must fit within real-world public health and clinical settings and be accessible and understandable to practitioners and the public.

The submission period for Implementation Sciences ideas ended on July 1. However, we encourage you to sign up for regular e-mail updates about the National Cancer Moonshot Initiative at the Cancer Moonshot Milestones web page.

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Pediatric Cancer

Cancer Research Ideas - Pediatric Cancer (Archived)

Children are not just small adults; their cancers are different in many ways from those in older individuals. Improving childhood cancer outcomes requires both a better mechanistic understanding of cancer in general as well as an understanding of cancer in children specifically. Important issues to address include the molecular drivers of childhood cancer, which are often different from those of adult cancers; the causes of childhood cancer; and the development of therapies that are less toxic to children’s developing bodies.

The submission period for Pediatric Cancer ideas ended on July 1. However, we encourage you to sign up for regular e-mail updates about the National Cancer Moonshot Initiative at the Cancer Moonshot Milestones web page.

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Precision Prevention & Early Detection

Cancer Research Ideas - Precision Prevention & Early Detection (Archived)

Advances in genomic technologies should lead to improved prevention and early detection strategies. As we develop a better understanding of common genetic variants that are associated with higher or lower risk of certain cancers, we may be able to use that knowledge to identify individuals who may or may not benefit from prevention strategies. And techniques to analyze bits of tumor DNA (and other molecules) that are released into the blood and other body fluids may enable noninvasive screening for very early cancers.

The submission period for Precision Prevention & Early Detection ideas ended on July 1. However, we encourage you to sign up for regular e-mail updates about the National Cancer Moonshot Initiative at the Cancer Moonshot Milestones web page.

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Tumor Evolution & Progression

Cancer Research Ideas - Tumor Evolution & Progression (Archived)

Cancer genomics has yielded a greater understanding of the mutations that occur within cancer cells and their roles in tumor initiation and progression. Concurrent with an increased understanding of cancer genomics, a greater appreciation has developed for the enormous heterogeneity of cancer cells that evolve within a tumor, the metabolic changes in both the cancer cell and immune cells in the microenvironment, and the roles of the non-cancer cellular and molecular components of the tumor microenvironment that both support and suppress tumor progression.

The submission period for Tumor Evolution & Progression ideas ended on July 1. However, we encourage you to sign up for regular e-mail updates about the National Cancer Moonshot Initiative at the Cancer Moonshot Milestones web page.

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Other Exceptional Opportunities

Cancer Research Ideas - Other Exceptional Opportunities (Archived)

Not sure where to enter your idea? Use this space for other ideas you may have that could provide exceptional opportunity for progress, including ways to improve the cancer research process, encourage collaborations, and achieve other goals important to advancing progress against cancer.

The submission period for Other Exceptional Opportunities ideas ended on July 1. However, we encourage you to sign up for regular e-mail updates about the National Cancer Moonshot Initiative at the Cancer Moonshot Milestones web page.

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Improve Clinical Trials Information – Patients, Caregivers, Advocates

Improve Clinical Trials Information – Patients, Caregivers, Advocates (Archived)

Have you been frustrated with how difficult it is to find clinical trials information? Do you have an idea that would help patients have a more informed discussion with their doctor about clinical trials? Submit your ideas or comment on ideas from others.

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Improve Clinical Trials Information – Health Professionals

Improve Clinical Trials Information – Health Professionals (Archived)

Do you have an idea that would help physicians like you find and recommend clinical trials to patients? What types of materials would make it easier for you to discuss clinical trials with your patients? Give us your ideas or comment on ideas from others.

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Clinical Trial Information for Technical Partners

Clinical Trial Information for Technical Partners (Archived)

Are you developing a digital product around cancer information or cancer clinical trials? Are you a digital publisher of cancer content? Do you have ideas about how NCI’s cancer clinical trials information can help you? Give us your ideas or comment on ideas from others.

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