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Grants on childhood cancer can be assigned to a study section with no pediatric oncologists and often a single reviewer is a pediatric oncologist. Funding is by percentile; a fair and informed review requires a pediatric oncology study section.
Funding decisions are basically made on opinions. A revolutionary concept would be to have metrics so that funding decisions could be made on the basis of data.
Cell lines + patient-derived xenografts (PDXs) enable biological and preclinical therapeutic studies informing clinical trials. Developing, characterizing and insuring distribution of such models for childhood cancers should be funded by NCI.