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Researchers lump in any number of human trialists from both familial, (usually around 10%), and sporadic diseases. No attempt is made to keep results from familial and sporadic diseases separate. Familial and sporadic results must be kept separate.
Cancer starts with a stalled, or the failure to start, G1 phase of the cell cycle. There are many reasons why this process becomes stalled. Familial cancers fail to start the G1 phase because a mutation prevents it. Adult cancers are stalled G1 phase
Cellular injury if stalled in the G1 phase causes the majority of sporadic, (adult), cancers.
The biggest requirement for new cells in a child will be in still developing cells, or cells with a quick turnover. These are cells where cancer could be produced if cell cycle is inhibited. At 6, the requirement to regenerate cells is diminished.
Most genetic mice used now only represent familial versions of disease, if they are developed with a mutation.
The information in the attachment explains how this discovery leads to disease and treatment markers, susceptibility tests that could predict the possibility of cancer before malignancy presents, and how it will lead to cellular specific treatments.