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One of the key sources of morbidity for radiation related dysphagia is the irradiation of the retropharyngeal nodes. No existing data. and TORS surgeons can sample retropharyngeal nodes.
Our research program will demonstrate that circulating DNA released from tumors after high-dose radiation (SBRT, SRS) can be used as an anatomically-directed liquid biopsy to aid in the diagnosis and management of cancer.
With new targeted drugs, revised treatment schedules offer new ways to optimize cancer treatments. New bio-mathematical optimization methods can thus fully utilize combined treatment approaches. Models can be patient-specific when based on imaging.
There is strong evidence that radiation therapy can trigger an anti-tumor immune response even leading to the disappearance of metastasis not radiated. We need to better understand the mechanisms involved.